2. Gene
  3. Shank3 - SH3 and multiple ankyrin repeat domains 3 Gene

Shank3 - SH3 and multiple ankyrin repeat domains 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Prosap2; Spank-2

基因 ID: 59312 | 基因类型: protein coding

关于 Shank3

功能概要

Enables several functions, including SH3 domain binding activity; protein C-terminus binding activity; and scaffold protein binding activity. A structural constituent of postsynaptic density. Involved in positive regulation of glutamate receptor signaling pathway and regulation of synapse organization. Located in ciliary membrane and synapse. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Used to study Phelan-McDermid syndrome. Human ortholog(s) of this gene implicated in Phelan-McDermid syndrome and schizophrenia 15. Orthologous to human SHANK3 (SH3 and multiple ankyrin repeat domains 3). [provided by Alliance of Genome Resources, Apr 2022]

Shank3 基因产物(1)

mRNA Protein Name
NM_021676.3 NP_067708.2 SH3 and multiple ankyrin repeat domains protein 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor binding IPI
IPI: 通过物理相互作用推断
10958799 RGD
enables SH3 domain binding IPI
IPI: 通过物理相互作用推断
15014124 RGD
enables identical protein binding IDA
IDA: 通过直接分析推断
16439662 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
10433268 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10433269 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
16439662 RGD
enables scaffold protein binding IPI
IPI: 通过物理相互作用推断
10433269 RGD
enables structural constituent of postsynaptic density IDA
IDA: 通过直接分析推断
10433269 RGD
enables structural constituent of postsynaptic density IMP
IMP: 通过突变表型推断
21217644 RGD
enables synaptic receptor adaptor activity IDA
IDA: 通过直接分析推断
10433269 RGD
enables zinc ion binding IDA
IDA: 通过直接分析推断
16439662 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of glutamate receptor signaling pathway IMP
IMP: 通过突变表型推断
21795692 RGD
involved in regulation of postsynapse organization IDA
IDA: 通过直接分析推断
21217644 RGD
involved in regulation of postsynapse organization IMP
IMP: 通过突变表型推断
21217644 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in ciliary membrane IDA
IDA: 通过直接分析推断
18596612 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
10433269 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
21217644 RGD
is active in postsynaptic density IDA
IDA: 通过直接分析推断
23719161 RGD
located in postsynaptic density IDA
IDA: 通过直接分析推断
10433269 RGD
is active in postsynaptic density IMP
IMP: 通过突变表型推断
23719161 RGD
is active in postsynaptic density, intracellular component IDA
IDA: 通过直接分析推断
15894489 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

SH3 and multiple ankyrin repeat domains protein 3

SH3/ankyrin domain gene 3

Shank postsynaptic density protein 3a

proline-rich synapse-associated protein 2

Shank3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Shank3 Q9JLU4 Arhgef7 Rattus norvegicus O55043
Anti Bait CoIP
12626503
种属内
Shank3 Q9JLU4 Abi1 Rattus norvegicus Q9QZM5
Anti Bait CoIP
17304222
种属内
Shank3 Q9JLU4 Camk2a Mus musculus P11798
Anti Tag CoIP
28130356
种属内
Shank3 Q9JLU4 Shank3 Rattus norvegicus Q9JLU4
Pull Down
10433268
种属内
Shank3 Q9JLU4 Rps6ka2 Mus musculus Q9WUT3
Y2H
16217014
种属内
Shank3 Q9JLU4 Abi1 Rattus norvegicus Q9QZM5
Pull Down
17304222
种属内
Shank3 Q9JLU4 Abi1 Rattus norvegicus Q9QZM5
Imaging
17304222
种属内
Shank3 Q9JLU4 Rps6ka3 Mus musculus P18654
Y2H
16217014
种属内
Shank3 Q9JLU4 Shank3 Rattus norvegicus Q9JLU4
Anti Tag CoIP
10433268
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-163345 5-HT7R antagonist 2 Antagonist / 否
HY-P10106 TAT-PAK18 inhibitory peptide Inhibitor / 否
HY-RS12852 SHANK3 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Shank3 NCBI NCBI:85358
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