ALOXE3 - arachidonate lipoxygenase 3 Gene

中文名称：花生四烯酸脂氧合酶 3

种属: Homo sapiens

同用名: ARCI3; E-LOX; eLOX3; eLOX-3

基因 ID: 59344 | 基因类型: protein coding

关于 ALOXE3

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,095,900-8,118,916 (from NCBI)

This gene has 4 transcripts (splice variants), 374 orthologues, 5 paralogues and is associated with 6 phenotypes. Restricted expression toward skin (RPKM 14.1).

功能概要

该基因是脂氧合酶家族的成员，可被花生四烯酸衍生的化合物分解代谢。编码的酶是一种氢过氧化物异构酶，可从 12R-氢过氧二十碳四烯酸 (12R-HPETE) 合成一种独特类型的环氧醇 (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) 。这种环氧醇可以激活与表皮分化有关的核受体过氧化物酶体增殖物激活受体α (PPARalpha) 。由该基因编码的酶的功能丧失导致鱼鳞病，表明该基因在人类皮肤分化中的功能。该基因是 17p13.1 上脂氧合酶基因簇的一部分。该基因的突变会导致非大疱性先天性鱼鳞病样红皮病 (NCIE) 。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2009 年 9 月]

This gene is a member of the Lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor Peroxisome Proliferator-activated Receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of Lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

ALOXE3 基因产物(3)

mRNA	Protein	Name
NM_001165960.1	NP_001159432.1	hydroperoxide isomerase ALOXE3 isoform 1
NM_001369446.1	NP_001356375.1	hydroperoxide isomerase ALOXE3 isoform 3
NM_021628.3	NP_067641.2	hydroperoxide isomerase ALOXE3 isoform 2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables hepoxilin A3 synthase activity	IDA IDA: 通过直接分析推断	12881489	GOA
enables intramolecular hydroxytransferase activity	IDA IDA: 通过直接分析推断	20923767	GOA
NOT enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IDA IDA: 通过直接分析推断	12881489	GOA
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IDA IDA: 通过直接分析推断	20921226	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	28514442	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in arachidonate metabolic process	IDA IDA: 通过直接分析推断	12881489	GOA
involved in hepoxilin biosynthetic process	IDA IDA: 通过直接分析推断	12881489	GOA
involved in linoleic acid metabolic process	IDA IDA: 通过直接分析推断	12881489	GOA
involved in lipoxygenase pathway	IDA IDA: 通过直接分析推断	20921226	GOA
involved in sphingolipid metabolic process	IDA IDA: 通过直接分析推断	21558561	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ALOXE3 蛋白结构

PLAT

Lipoxygenase

0
200
400
600
711 a.a.

蛋白主名

其他名称

hydroperoxide isomerase ALOXE3

Epidermal lipoxygenase-3

关联疾病

疾病名称

别名

Ichthyosis, Congenital, Autosomal Recessive 3

Autosomal Recessive Congenital Ichthyosis 3	ARCI3
Lamellar Ichthyosis 5	Collodion Baby, Self-Healing
Ichthyosis, Lamellar, 5, Formerly	Li5, Formerly
Li5	Self-Healing Collodion Baby
Ichthyosis, Congenital, Autosomal Recessive, Type 3

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Ichthyosis, Congenital, Autosomal Recessive 2

Autosomal Recessive Congenital Ichthyosis 2	ARCI2
Ncie1	Ichthyosiform Erythroderma, Congenital
Collodion Baby, Self-Healing	Ichthyosiform Erythroderma, Nonbullous Congenital, 1, Formerly
Ncie1, Formerly	Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form, Formerly
Brocq Congenital Ichthyosiform Erythroderma Nonbullous Form	Nonbullous Congenital Ichthyosiform Erythroderma 1
Cie	Ichthyosiform Erythroderma Brocq Congenital Non-Bullous Form
Iecn1	Non-Bullous Congenital Ichthyosiform Erythroderma Type 1
Self-Healing Collodion Baby	Ichthyosis, Congenital, Autosomal Recessive, Type 2
Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Self-Improving Collodion Baby

Self-Healing Collodion Baby	Shcb
Sici	Self-Improving Congenital Ichthyosis

Ichthyosis, Congenital, Autosomal Recessive 1

Collodion Fetus	Autosomal Recessive Congenital Ichthyosis 1
ARCI1	Ichthyosis Congenita
Lamellar Exfoliation Of Newborn	Desquamation Of Newborn
Ichthyosis Congenita Ii	Shcb
Icr2	Bathing Suit Ichthyosis
Li1	Self-Healing Collodion Baby
Ichthyosis, Congenital, Autosomal Recessive 1, With Bathing Suit Distribution	Collodion Baby, Self-Healing
Ichthyosis, Lamellar, 1, Formerly	Li1, Formerly
Ichthyosis Lamellar 1	Lamellar Ichthyosis, Type 1
Bsi	Autosomal Recessive Congenital Ichthyosis 1 With Bathing Suit Distribution
Autosomal Recessive Congenital Ichthyosis Tgm1-Related	Lamellar Ichthyosis 1
Non-Erythrodermic Ichthyosis	Ichthyosis, Congenital, Autosomal Recessive, Type 1
Congenital Ichthyosis

Trichothiodystrophy 1, Photosensitive

TTD1	Tay Syndrome
Trichothiodystrophy With Congenital Ichthyosis	Photosensitive Trichothiodystrophy
Ibids Syndrome	Ttdp
Ichthyosiform Erythroderma With Hair Abnormality And Mental And Growth Retardation	Ichthyosis, Congenital, With Trichothiodystrophy
Pibids Syndrome	Photosensitive Trichothiodystrophy 1
Trichothiodystrophy, Photosensitive	Sulfur-Deficient Brittle Hair Syndrome
Ttd-P	Ichthyosis With Brittle Hair, Intellectual Impairment, Decreased Fertility And Short Stature
Trichothiodystrophy Photosensitive	Trichothiodystrophy, Type 1
Tricho-Thiodystrophy Disorder	Trichothiodystrophy Syndromes
Amish Brittle Hair Brain Syndrome

Ichthyosis, Congenital, Autosomal Recessive 4b

Harlequin Ichthyosis	Autosomal Recessive Congenital Ichthyosis 4b
Hi	Harlequin Fetus
ARCI4B	Ichthyosis Congenita, Harlequin Fetus Type
Harlequin Type Ichthyosis	'Harlequin Fetus'
Harlequin Type Ichthyosis Congenita	Harlequin Type Ichthyosis Fetalis
Harlequin Baby Syndrome	Ichthyosis Congenita, Harlequin Type
Ichthyosis Fetalis, Harlequin Type	Ichthyosis Congenita Harlequin Fetus Type
Ichthyosis, Harlequin	Ichthyosis, Congenital, Autosomal Recessive, Type 4b

Ichthyosis, Congenital, Autosomal Recessive 7

ARCI7

Autosomal Recessive Congenital Ichthyosis 7

Tinea Profunda

Deep Seated Dermatophytosis	Granuloma Trichophyticum
Majocchi'S Granuloma

Epidermolytic Hyperkeratosis

Bullous Congenital Ichthyosiform Erythroderma	Bullous Ichthyosiform Erythroderma
EHK	Bullous Erythroderma Ichthyosiformis Congenita Of Brocq
Bcie	Bie
Epidermolytic Ichthyosis	Ichthyosis Bullosa Of Siemens
Superficial Epidermolytic Ichthyosis	Hyperkeratosis, Epidermolytic
Congenital Bullous Ichthyosiform Erythroderma	Bullous Type Ichthyosis
Epidermolytic Palmoplantar Hyperkeratosis	Bullous Ichthyosiform Erythroderma Congenita
Bullous Erythroderma Ichthyosiforme	Sei
Epidermolytic Hyperkeratosis Late-Onset	Epidermolytic Hyperkeratosis, Late-Onset

Ectropion

Ectropion Of Eyelid	Everted Margin
Eversion Of The Eyelid	Eyelashes Turned Out
Eyelid Everted	Eyelid Turned Out
Unspecified Ectropion Of Unspecified Eye

X-Linked Chondrodysplasia Punctata 2

Happle Syndrome	Cdpx2
Conradi-Hünermann Syndrome	Chondrodysplasia Punctata 2, X-Linked
X-Linked Dominant Chondrodysplasia Punctata	Conradi-Hunermann Syndrome
Conradi-Hünermann-Happle Syndrome	Cdpxd
Cpxd	Chondrodystrophia Calcificans Congenita
Conradi-Hunermann-Happle Syndrome	X-Linked Chondrodysplasia Punctata Type 2
Chondrodysplasia Punctata, X-Linked Dominant Type

Eyelid Disease

Eyelid Diseases

Eyelid Disorders

Ichthyosis, X-Linked

X-Linked Ichthyosis	Steroid Sulfatase Deficiency
Placental Steroid Sulfatase Deficiency	Steroid Sulfatase Deficiency Disease
XLI	Sts Deficiency
Ssdd	X-Linked Recessive Ichthyosis
X-Linked Ichthyosis With Steryl-Sulphatase Deficiency	X-Linked Placental Steryl-Sulphatase Deficiency
Ssd	X Linked Ichthyosis
Recessive X-Linked Ichthyosis	Rxli
Syndromic Recessive X-Linked Ichthyosis	Recessive X-Linked Ichthyosis With Extracutaneous Manifestations
Syndromic Rxli	X-Linked Ichthyosis Syndrome
IXL	Ichthyosis X-Linked
Sex-Linked Ichthyosis	X-Linked Ichthyosis With Steryl-Sulfatase Deficiency

Ichthyosis Vulgaris

Ichthyosis Simplex	Dominant Congenital Ichthyosiform Erythroderma
Common Ichthyosis	Fish Scale Disease
VI	Ichthyoses
Congenital Ichthyosis

Peeling Skin Syndrome

Deciduous Skin	Familial Continuous Skin Peeling Syndrome
Idiopathic Deciduous Skin	Keratosis Exfoliativa Congenita
Pss	Peeling Skin Disease
Skin Peeling Syndrome	Familial Continuous Skin Peeling
Keratolysis Exfoliativa Congenita	Exfoliation Syndrome
Keratolysis Exfoliativa

Chanarin-Dorfman Syndrome

Neutral Lipid Storage Disease	CDS
Neutral Lipid Storage Disease With Ichthyosis	Triglyceride Storage Disease With Impaired Long-Chain Fatty Acid Oxidation
Triglyceride Storage Disease With Ichthyosis	Nlsdi
Ichthyotic Neutral Lipid Storage Disease	Dorfman-Chanarin Syndrome
Dcs	Chanarin-Dorfman Disease
Ichthyosiform Erythroderma With Leukocyte Vacuolation	Lipidosis With Triglyceride Storage Disease
Disorder Of Cornification 12	Dorfman Chanarin Syndrome
Neutral Lipid Storage Disease With Ichthyotic	Dorfman-Chanarin Disease

Congenital Hemidysplasia With Ichthyosiform Erythroderma And Limb Defects

Child Syndrome	Ichthyosiform Erythroderma, Unilateral, With Ipsilateral Malformations, Especially Absence Deformity Of Limbs
Child Nevus	Congenital Hemidysplasia With Ichthyosiform Nevus And Limbs Defects
Congenital Hemidysplasia With Ichthyosiform Nevus And Limb Defects	Ichthyosis, Child Syndrome
Child Syndrome Ichthyosis	CHILD

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N15742	Talaroconvolutin A		/	否
HY-RS00626	ALOXE3 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	ALOXE3	RGD	RGD:1306252
Macaca mulatta	ALOXE3	VGNC	VGNC:69607
Felis catus	ALOXE3	VGNC	VGNC:59758
Canis familiaris	ALOXE3	VGNC	VGNC:37814
Bos taurus	ALOXE3	VGNC	VGNC:25846
Mus musculus	ALOXE3	MGD	MGI:1345140

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ALOXE3 - arachidonate lipoxygenase 3 Gene

关于 ALOXE3

功能概要

ALOXE3 基因产物(3)

ALOXE3 蛋白结构

关联疾病

直系同源

热门区域

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ALOXE3 - arachidonate lipoxygenase 3 Gene

关于 ALOXE3

功能概要

ALOXE3 基因产物(3)

ALOXE3 蛋白结构

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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