RPL3 - ribosomal protein L3 Gene

中文名称：核糖体蛋白 L3

种属: Homo sapiens

同用名: L3; ASC-1; TARBP-B

基因 ID: 6122 | 基因类型: protein coding

关于 RPL3

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,312,882-39,319,623 (from NCBI)

This gene has 18 transcripts (splice variants), 229 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 2560.0), skin (RPKM 1107.2) and 25 other tissues.

功能概要

核糖体是催化蛋白质合成的复合物，由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由 4 种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码的核糖体蛋白是 60S 亚基的一个组成部分。该蛋白属于核糖体蛋白 L3P 家族，位于细胞质中。该蛋白质可以与 HIV-1 TAR mRNA 结合，并且有人认为该蛋白质有助于 tat 介导的反式激活。该基因与几个小的核仁 RNA 基因共同转录，这些基因位于该基因的几个内含子中。已经表征了编码不同亚型的替代转录剪接变体。作为典型的编码核糖体蛋白的基因，该基因有多个经过处理的假基因分散在基因组中。[RefSeq 提供，2008 年 7 月]

Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPL3 基因产物(2)

mRNA	Protein	Name
NM_000967.4	NP_000958.1	60S ribosomal protein L3 isoform a
NM_001033853.2	NP_001029025.1	60S ribosomal protein L3 isoform b

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	23349634	GOA
enables structural constituent of ribosome	IDA IDA: 通过直接分析推断	23636399	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of cytosolic large ribosomal subunit	IDA IDA: 通过直接分析推断	32669547	GOA
is active in cytosolic ribosome	IDA IDA: 通过直接分析推断	32669547	GOA
located in cytosolic ribosome	IDA IDA: 通过直接分析推断	23636399	GOA
located in nucleolus	IDA IDA: 通过直接分析推断	16963496	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	23349634	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPL3 蛋白结构

Ribosomal_L3

0
100
200
300
403 a.a.

蛋白主名

其他名称

60S ribosomal protein L3

HIV-1 TAR RNA-binding protein B

RPL3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RPL3	P39023	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
种属内	RPL3	P39023	WFS1	Homo sapiens	O76024	Y2H Array	32814053
种属内	RPL3	P39023	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Shwachman-Diamond Syndrome 1

Shwachman-Diamond Syndrome	Shwachman Syndrome
Shwachman-Bodian-Diamond Syndrome	Sds
Pancreatic Insufficiency And Bone Marrow Dysfunction	Shwachman-Bodian Syndrome
SDS1	Lipomatosis Of Pancreas, Congenital
Congenital Lipomatosis Of Pancreas	Shwachman-Diamond Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia, Shwachman Type	Shwachman-Diamond-Oski Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12184	RPL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS12198	RPL3L Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS22308	Rpl3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS28830	Rpl3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	RPL3	VGNC	VGNC:101451
Rattus norvegicus	RPL3	RGD	RGD:735105
Felis catus	RPL3	VGNC	VGNC:97609
Mus musculus	RPL3	MGD	MGI:1351605

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RPL3 - ribosomal protein L3 Gene

关于 RPL3

功能概要

RPL3 基因产物(2)

RPL3 蛋白结构

RPL3 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

RPL3 - ribosomal protein L3 Gene

关于 RPL3

功能概要

RPL3 基因产物(2)

RPL3 蛋白结构

RPL3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z