2. Gene
  3. BDKRB1 - bradykinin receptor B1 Gene

BDKRB1 - bradykinin receptor B1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：缓激肽受体 B1

种属: Homo sapiens

同用名: B1R; BKR1; B1BKR; BKB1R; BRADYB1

基因 ID: 623 | 基因类型: protein coding

关于 BDKRB1

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:96,256,210-96,264,763 (from NCBI)

This gene has 4 transcripts (splice variants), 147 orthologues and 7 paralogues. Biased expression in gall bladder (RPKM 7.4), urinary bladder (RPKM 5.2) and 12 other tissues.

功能概要

缓激肽是一种由 9 个氨基酸组成的肽，在炎症、外伤、烧伤、休克和过敏等病理生理条件下产生。该基因编码的蛋白质属于 G 蛋白偶联受体 1 家族。已发现两种类型的 G 蛋白偶联受体，它们结合缓激肽并介导对这些病理生理状况的反应。由该基因编码的蛋白质是这些受体之一，并在组织损伤后从头合成。受体结合导致细胞溶质钙离子浓度增加，最终导致慢性和急性炎症反应。[RefSeq 提供，2020 年 8 月]

Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The protein encoded by this gene belongs to the G-protein coupled receptor 1 family. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. [provided by RefSeq, Aug 2020]

BDKRB1 基因产物(2)

mRNA Protein Name
NM_001386007.1 NP_001372936.1 B1 bradykinin receptor
NM_000710.4 NP_000701.2 B1 bradykinin receptor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables bradykinin receptor activity IDA
IDA: 通过直接分析推断
1314587 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23597562 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BDKRB1 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (54 - 312)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
蛋白主名 其他名称

B1 bradykinin receptor

BK-1 receptor

bradykinin B1 receptor

bradykinin receptor 1

BDKRB1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
BDKRB1 P46663 P01042-PRO_0000006687 Homo sapiens P01042-PRO_0000006687
SPA
23597562
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Erysipelas
Milker'S Nodule

Poxviridae Infections

Milker Nodule

Milkers' Node

Paravaccinia

Pseudocowpox

Milker'S Nodes
Angioedema

Angioneurotic Oedema

Quincke'S Edema

Angioneurotic Edema

Giant Urticaria
Covid-19

2019 Novel Coronavirus

2019-Ncov Infection

Covid19

Sars-Cov-2 Infection

Wuhan Coronavirus Infection

Wuhan Seafood Market Pneumonia Virus Infection
End Stage Renal Disease

End Stage Renal Failure

End-Stage Kidney Disease

Kidney Failure, Chronic

Chronic Kidney Disease Stage 5
Hereditary Angioedema

Hereditary Angioneurotic Edema

Hereditary Angioedema Type 1

Hane

Angioedema, Hereditary

Hae

Angioedemas, Hereditary

Deficiency Of C1 Esterase Inhibitor

C1 Esterase Inhibitor Deficiency

C1 Inhibitor Deficiency

Familial Angioneurotic Edema

Hereditary Bradykinine-Induced Angioedema

Hereditary Non Histamine-Induced Angioedema

Hae 1

Hae-I

Hereditary Angioneurotic Edema Type 1

Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor

Hereditary Angioedema Types I And Ii

Hereditary Angioneurotic Oedema

Familial Angioedema

Hae - [Hereditary Angioneurotic Oedema]

Bannister Disease, Hereditary

Quincke Disease Or Oedema

Hereditary Quincke Oedema
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01454 BDKRB1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS01455 Bdkrb1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS01456 Bdkrb1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus BDKRB1 VGNC VGNC:26459
Rattus norvegicus BDKRB1 RGD RGD:620401
Mus musculus BDKRB1 MGD MGI:88144
Canis familiaris BDKRB1 VGNC VGNC:38424
Macaca mulatta BDKRB1 VGNC VGNC:70043
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