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  2. RRM1 - ribonucleotide reductase catalytic subunit M1 Gene

RRM1 - ribonucleotide reductase catalytic subunit M1 Gene

中文名称:核糖核苷酸还原酶催化亚基 M1

种属: Homo sapiens

同用名: R1; RR1; RIR1

基因 ID: 6240 | 基因类型: protein coding

关于 RRM1

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:4,094,685-4,138,932 (from NCBI)

This gene has 14 transcripts (splice variants) and 260 orthologues. Ubiquitous expression in skin (RPKM 18.5), lymph node (RPKM 18.3) and 25 other tissues.

功能概要

该基因编码核糖核苷酸还原酶的大催化亚基,核糖核苷酸还原酶是将核糖核苷酸转化为脱氧核糖核苷酸所必需的酶。可用的脱氧核糖核苷酸池对于细胞周期 S 期的 DNA 复制以及多个 DNA 修复过程很重要。可变剪接导致多个转录本变体。[RefSeq 提供,2015 年 12 月]

This gene encodes the large and catalytic subunit of ribonucleotide reductase, an Enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

RRM1 基因产物(4)

mRNA Protein Name
NM_001033.5 NP_001024.1 ribonucleoside-diphosphate reductase large subunit isoform 1
NM_001318064.1 NP_001304993.1 ribonucleoside-diphosphate reductase large subunit isoform 2
NM_001318065.1 NP_001304994.1 ribonucleoside-diphosphate reductase large subunit isoform 3
NM_001330193.1 NP_001317122.1 ribonucleoside-diphosphate reductase large subunit isoform 4

RRM1 蛋白结构

ATP-cone

ATP-cone: ATP cone domain (1 - 89)

Ribonuc_red_lgN

Ribonuc_red_lgN: Ribonucleotide reductase, all-alpha domain (142 - 212)

Ribonuc_red_lgC

Ribonuc_red_lgC: Ribonucleotide reductase, barrel domain (215 - 739)

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  • 600
  • 792 a.a.
蛋白主名 其他名称

ribonucleoside-diphosphate reductase large subunit

ribonucleoside-diphosphate reductase subunit M1

重组 RRM1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74591 RRM1 Protein, Human (sf9, His-GST) P23921 (M1-S792) ≥95%

关联疾病

疾病名称 别名
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Immunodeficiency 25

Immunodeficiency Due To Defect In Cd3-Zeta

IMD25

Immunodeficiency, Type 25

Retinitis Pigmentosa 7

Leber Congenital Amaurosis 18

RP7

Retinitis Pigmentosa 7, Digenic Form

Retinitis Pigmentosa 7 And Digenic Form

Retinitis Pigmentosa 7, Digenic

LCA18

Retinitis Pigmentosa 7 Digenic

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus RRM1 VGNC VGNC:34164
Rattus norvegicus RRM1 RGD RGD:1592569
Canis familiaris RRM1 VGNC VGNC:45760
Macaca mulatta RRM1 VGNC VGNC:76941
Mus musculus RRM1 MGD MGI:98180
Felis catus RRM1 VGNC VGNC:64775
Others RRM1 NCBI