SLC22A23 - solute carrier family 22 member 23 Gene

中文名称：溶质载体家族 22 成员 23

种属: Homo sapiens

同用名: C6orf85

基因 ID: 63027 | 基因类型: protein coding

关于 SLC22A23

Cytogenetic location: 6p25.2 Genomic coordinates (GRCh38): 6:3,268,973-3,457,050 (from NCBI)

This gene has 12 transcripts (splice variants), 327 orthologues and 22 paralogues. Ubiquitous expression in stomach (RPKM 8.9), colon (RPKM 8.8) and 25 other tissues.

功能概要

SLC22A23 属于跨膜蛋白大家族，可作为单向转运体、同向转运体和反向转运体将有机离子转运跨细胞膜 (Jacobsson 等人，2007 [PubMed 17714910]) 。[OMIM 提供，2008 年 3 月]

SLC22A23 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008]

SLC22A23 基因产物(9)

mRNA	Protein	Name
NM_001286455.1	NP_001273384.1	solute carrier family 22 member 23 isoform b
NM_001286456.2	NP_001273385.1	solute carrier family 22 member 23 isoform c
NM_001382317.1	NP_001369246.1	solute carrier family 22 member 23 isoform d
NM_001382318.1	NP_001369247.1	solute carrier family 22 member 23 isoform e
NM_001382319.1	NP_001369248.1	solute carrier family 22 member 23 isoform f
NM_001382320.1	NP_001369249.1	solute carrier family 22 member 23 isoform g
NM_001382321.1	NP_001369250.1	solute carrier family 22 member 23 isoform h
NM_015482.2	NP_056297.1	solute carrier family 22 member 23 isoform a
NM_021945.6	NP_068764.3	solute carrier family 22 member 23 isoform b

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC22A23 蛋白结构

Sugar_tr

0
200
400
600
686 a.a.

蛋白主名

其他名称

solute carrier family 22 member 23

ion transporter protein

SLC22A23 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SLC22A23	A1A5C7	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
种属内	SLC22A23	A1A5C7	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	25416956
种属内	SLC22A23	A1A5C7	KRTAP5-9	Homo sapiens	P26371	Y2H Array	25416956
种属内	SLC22A23	A1A5C7	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	25416956
种属内	SLC22A23	A1A5C7	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
种属内	SLC22A23	A1A5C7	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	31515488
种属内	SLC22A23	A1A5C7	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome	WHS
Chromosome 4p16.3 Deletion Syndrome	Wittwer Syndrome
4p- Syndrome	Pitt Syndrome
4p Deletion Syndrome	Distal Deletion 4p
Distal Monosomy 4p	Telomeric Deletion 4p
Prds	4p Syndrome
Chromosome 4p Syndrome	Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation
Wolf Syndrome	Chromosome 4p Deletion Syndrome
Chromosome 4p Monosomy	Del Syndrome
Monosomy 4p	Partial Monosomy 4p
Chromosome 4 Short Arm Deletion

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13073	SLC22A23 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	SLC22A23	VGNC	VGNC:83466
Mus musculus	SLC22A23	MGD	MGI:1920352
Rattus norvegicus	SLC22A23	RGD	RGD:620302
Canis familiaris	SLC22A23	VGNC	VGNC:59141
Bos taurus	SLC22A23	VGNC	VGNC:54236
Felis catus	SLC22A23	VGNC	VGNC:65244
Others	SLC22A23	NCBI

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