CCL8 - C-C motif chemokine ligand 8 Gene

中文名称：CC 基序趋化因子配体 8

种属: Homo sapiens

同用名: HC14; MCP2; MCP-2; SCYA8; SCYA10

基因 ID: 6355 | 基因类型: protein coding

关于 CCL8

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:34,319,435-34,321,402 (from NCBI)

This gene has 1 transcript (splice variant), 101 orthologues and 25 paralogues. Broad expression in small intestine (RPKM 5.2), fat (RPKM 4.6) and 22 other tissues.

功能概要

这种抗菌基因是聚集在 17 号染色体 q 臂上的几种趋化因子基因之一。趋化因子形成了一个参与免疫调节和炎症过程的分泌蛋白超家族。基于成熟肽的 N 末端半胱氨酸残基的排列，该超家族分为四个亚家族。该趋化因子是 CC 亚家族的成员，其特征在于两个相邻的半胱氨酸残基。该细胞因子显示出对单核细胞、淋巴细胞、嗜碱性粒细胞和嗜酸性粒细胞的趋化活性。通过将白细胞募集到炎症部位，这种细胞因子可能有助于肿瘤相关的白细胞浸润和抗 HIV 感染的抗病毒状态。[RefSeq 提供，2014 年 9 月]

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the Antiviral state against HIV Infection. [provided by RefSeq, Sep 2014]

CCL8 基因产物(1)

mRNA	Protein	Name
NM_005623.3	NP_005614.2	C-C motif chemokine 8 precursor

CCL8 蛋白结构

IL8

0
99 a.a.

蛋白主名

其他名称

C-C motif chemokine 8

chemokine (C-C motif) ligand 8

重组 CCL8 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7238	MCP-2/CCL8 Protein, Human	P80075 (Q24-P99)	≥95%
HY-P7770	MCP-2/CCL8 Protein, Human (HEK293, His)	P80075 (Q24-P99)	≥95%
HY-P75923	MCP-2/CCL8 Protein, Human (SUMO)	P80075 (Q24-P99)	≥95%

关联疾病

疾病名称

别名

Tenosynovitis

Inflammation Of Tendon Sheath

Synovitis Or Tenosynovitis

Tendinitis

Tendinopathy

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Capillary Lymphangioma

Microcystic Lymphatic Malformation	Capillary Lymphatic Malformation
Microcystic Infiltrating Lymphatic Malformation	Microcystic Lymphangioma
Superficial Lymphangioma	Cutaneous Lymphangioma Circumscriptum
Superficial Lymphatic Malformation	Cutaneous Lymphangioma
Lymphangioma Of Skin	Lymphangioma Circumscriptum

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-B0498	Bindarit	Inhibitor	99.68%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02107	CCL8 Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	CCL8	VGNC	VGNC:55561
Felis catus	CCL8	VGNC	VGNC:98778
Mus musculus	CCL8	MGD	MGI:101878
Macaca mulatta	CCL8	VGNC	VGNC:70702
Others	CCL8	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

站点地图隐私声明

CCL8 - C-C motif chemokine ligand 8 Gene

关于 CCL8

功能概要

CCL8 基因产物(1)

CCL8 蛋白结构

重组 CCL8 蛋白

关联疾病

直系同源

热门区域

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CCL8 - C-C motif chemokine ligand 8 Gene

关于 CCL8

功能概要

CCL8 基因产物(1)

CCL8 蛋白结构

重组 CCL8 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z