1. Gene
  2. CXCL11 - C-X-C motif chemokine ligand 11 Gene

CXCL11 - C-X-C motif chemokine ligand 11 Gene

中文名称:CXC 基序趋化因子配体 11

种属: Homo sapiens

同用名: IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B

基因 ID: 6373 | 基因类型: protein coding

关于 CXCL11

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:76,033,682-76,036,070 (from NCBI)

This gene has 2 transcripts (splice variants), 88 orthologues and 12 paralogues. Broad expression in appendix (RPKM 6.2), lymph node (RPKM 5.0) and 21 other tissues.

功能概要

趋化因子是一组小的 (大约 8 到 14 kD) ,主要是基本的、结构相关的分子,它们通过与 7 跨膜 G 蛋白偶联受体的一个子集相互作用来调节各种类型白细胞的细胞运输。趋化因子还在免疫系统的发育、稳态和功能中发挥重要作用,并且它们对中枢神经系统的细胞以及参与血管生成或血管抑制的内皮细胞有影响。趋化因子分为 2 个主要亚家族,CXC 和 CC。这种抗菌基因是趋化因子超家族的 CXC 成员。其编码的蛋白质在活化的 T 细胞中诱导趋化反应,是 CXC 受体 3 的主要配体。编码该蛋白的基因包含 4 个外显子和至少三个可能反映细胞特异性表达调节的聚腺苷酸化信号。 IFN-γ 是该基因转录的有效诱导剂。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供,2014 年 10 月]

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

CXCL11 基因产物(2)

mRNA Protein Name
NM_001302123.2 NP_001289052.1 C-X-C motif chemokine 11 isoform 2 precursor
NM_005409.5 NP_005400.1 C-X-C motif chemokine 11 isoform 1 precursor

CXCL11 蛋白结构

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (28 - 89)

  • 0
  • 94 a.a.
蛋白主名 其他名称

C-X-C motif chemokine 11

beta-R1

重组 CXCL11 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7228 I-TAC/CXCL11 Protein, Human (HEK293) O14625 (F22-F94) ≥95%
HY-P7229 I-TAC/CXCL11 Protein, Human O14625 (F22-F94) ≥95%
HY-P700042AF Animal-Free I-TAC/CXCL11 Protein, Human (His) O14625 (F22-F94) ≥95%

关联疾病

疾病名称 别名
Nasal Cavity Adenocarcinoma

Adenocarcinoma Of Nasal Cavity

Adenocarcinoma Of The Nasal Cavity

Nasal Cavity Cancer

Nasal Cavity Carcinoma

Malignant Neoplasm Of Nasal Cavities

Malignant Tumor Of The Nasal Cavity

Cancer Of Nasal Cavity

Carcinoma Of Nasal Cavity

Malignant Neoplasm Of Nasal Cavity

Neoplasm Of Nasal Cavity

Mycosis Fungoides

Mycosis Fungoides Lymphoma

Alibert-Bazin Syndrome

Granuloma Fungoides

Classic Mycosis Fungoides

Mycosis Fungoides, Alibert-Bazin Type

American Histoplasmosis

Infection By Histoplasma Capsulatum

Ethmoid Sinus Adenocarcinoma

Adenocarcinoma Of Ethmoid Sinus

Adenocarcinoma Of The Ethmoid Sinus

Dermatitis

Eczema

Skin Inflammation

Inflammatory Dermatosis

Cryoglobulinemia

Cryoimmunoglobulinaemia

Breast Duct Papilloma

Intraductal Papilloma Of Breast

Duct Papilloma Of Breast

Papilloma Of The Breast

Allergic Contact Dermatitis

Dermatitis, Allergic Contact

Contact Dermatitis, Allergic

Dermatitis Allergic Contact

Allergic Contact Eczema

Acd - [Allergic Contact Dermatitis]

Allergic Contact Dermatitis, Unspecified Cause

Allergic Dermatitis

Allergic Eczema

Allergy Dermatitis

Allergy Eczema

Allergic Contact Eczema Due To Clothing Or Footwear

Perfume Allergic Contact Dermatitis

Allergic Contact Dermatitis Due To Cosmetics

Allergic Contact Eczema Due To Cosmetics Or Fragrances

Allergic Contact Eczema Due To Dental Materials

Allergic Contact Eczema Due To Food Flavours Or Additives

Allergic Contact Eczema Due To Hairdressing Products

Allergic Contact Eczema Due To Metals Or Metal Salts

Allergic Contact Eczema Due To Proteins

Allergic Contact Eczema Due To Plastics Or Resin Systems

Allergic Contact Eczema Due To Preservatives Or Biocides

Allergic Contact Eczema Due To Rubber Chemicals

Rubber Dermatitis

Allergic Contact Eczema Due To Systemic Medicaments

Allergic Contact Eczema Due To Topical Medicaments

Allergic Contact Dermatitis Due To Drugs In Contact With Skin

Relapsing-Remitting Multiple Sclerosis

Relapsing-Remitting Ms

Relapsing Remitting Multiple Sclerosis

Multiple Sclerosis, Relapsing-Remitting

Rrms

Multiple Sclerosis Relapsing-Remitting

Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord

Nasal Cavity Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Nasal Cavity

Squamous Cell Carcinoma Of The Nasal Cavity

Maxillary Sinus Adenocarcinoma

Adenocarcinoma Of Maxillary Sinus

Adenocarcinoma Of The Maxillary Sinus

Ethmoid Sinus Cancer

Malignant Neoplasm Of Ethmoidal Sinus

Malignant Tumor Of Ethmoid Sinus

Malignant Tumor Of Ethmoidal Sinus

Neoplasm Of Ethmoidal Sinus

Retroperitoneal Hemangiopericytoma
Sinonasal Undifferentiated Carcinoma

Highly Aggressive Undifferentiated Carcinoma Of The Nasal Cavity And Paranasal Sinuses

Snuc

Paranasal Sinus Cancer

Paranasal Sinus Adenoid Cystic Carcinoma

Paranasal Sinus Mucoepidermoid Carcinoma

Paranasal Sinus Squamous Cell Carcinoma

Paranasal Sinus Neoplasms

Adenoid Cystic Carcinoma Of Accessory Sinus

Adenoid Cystic Carcinoma Of Paranasal Sinus

Epidermoid Carcinoma Of The Paranasal Sinus

Mucoepidermoid Carcinoma Of Accessory Sinus

Paranasal Sinus Adenocarcinoma

Squamous Cell Carcinoma Of Paranasal Sinus

Paranasal Sinus Neoplasm

Adenocarcinoma Of Accessory Sinus

Olmsted Syndrome, X-Linked

OLMSX

Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques, X-Linked

Ppkmx

X-Linked Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

X-Linked Olmsted Syndrome

Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques, X-Linked

Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria

Pediculus Humanus Corporis Infestation

Body Louse Infestation

Pediculus Corporis

Pediculus Humanus Infestation

Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Immunodeficiency 27a

IMD27A

Autosomal Recessive Ifngr1 Deficiency

Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis

Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency

Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency

Autosomal Recessive Msmd Due To Partial Ifngammar1 Deficiency

Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency

Immunodeficiency 27a, Mycobacteriosis, Autosomal Recessive

Ifngr1 Deficiency, Autosomal Recessive

Immunodeficiency 27a, Mycobacteriosis, Ar

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar1 Deficiency

Msmd Due To Complete Ifngammar1 Deficiency

Msmd Due To Complete Interferon Gamma Receptor 1 Deficiency

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 1 Deficiency

Familial Disseminated Atypical Mycobacterial Infection

Interferon Gamma, Receptor 1, Deficiency

Immunodeficiency, Type 27a, Mycobacteriosis, Ar

Mycobacterial Disease, Mendelian Susceptibility To

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CXCL11 RGD RGD:727827
Macaca mulatta CXCL11 VGNC VGNC:106564
Mus musculus CXCL11 MGD MGI:1860203
Felis catus CXCL11 VGNC VGNC:78477
Bos taurus CXCL11 VGNC VGNC:27847
Susscrofa domestica CXCL11 NCBI
Others CXCL11 NCBI