1. Gene
  2. XCL1 - X-C motif chemokine ligand 1 Gene

XCL1 - X-C motif chemokine ligand 1 Gene

中文名称:XC 基序趋化因子配体 1

种属: Homo sapiens

同用名: LTN; ATAC; LPTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a

基因 ID: 6375 | 基因类型: protein coding

关于 XCL1

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:168,576,605-168,582,069 (from NCBI)

This gene has 1 transcript (splice variant), 116 orthologues and 25 paralogues. Low expression observed in reference dataset.

功能概要

这种抗菌基因编码趋化因子超家族的一个成员。趋化因子在炎症和免疫反应中起作用,诱导白细胞迁移和激活。编码的蛋白质是 C 趋化因子亚家族的成员,仅保留在其他趋化因子中保守的四个半胱氨酸中的两个,并且被认为对 T 细胞具有特异性趋化作用。该基因和一个密切相关的家族成员位于 1 号染色体的长臂上。[RefSeq 提供,2014 年 9 月]

This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in Other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]

XCL1 基因产物(1)

mRNA Protein Name
NM_002995.3 NP_002986.1 lymphotactin precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chemokine activity IDA
IDA: 通过直接分析推断
7602097 GOA
enables chemokine receptor binding IDA
IDA: 通过直接分析推断
9632725 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28381538 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
11889129 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: 通过直接分析推断
12949249 GOA
involved in cell-cell signaling IDA
IDA: 通过直接分析推断
7602097 GOA
involved in killing of cells of another organism IDA
IDA: 通过直接分析推断
12949249 GOA
involved in mature natural killer cell chemotaxis IDA
IDA: 通过直接分析推断
9029087 GOA
involved in negative regulation of CD4-positive, alpha-beta T cell proliferation IDA
IDA: 通过直接分析推断
10887101 GOA
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
10887101 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
10887101 GOA
involved in negative regulation of T cell cytokine production IDA
IDA: 通过直接分析推断
10887101 GOA
involved in negative regulation of T-helper 1 cell activation IDA
IDA: 通过直接分析推断
10887101 GOA
involved in negative regulation of interleukin-2 production IDA
IDA: 通过直接分析推断
10887101 GOA
involved in negative regulation of type II interferon production IDA
IDA: 通过直接分析推断
10887101 GOA
involved in positive regulation of CD8-positive, alpha-beta T cell proliferation IDA
IDA: 通过直接分析推断
10887101 GOA
involved in positive regulation of T cell chemotaxis IDA
IDA: 通过直接分析推断
7602097 GOA
involved in positive regulation of T cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
18832695 GOA
involved in positive regulation of granzyme A production IDA
IDA: 通过直接分析推断
18832695 GOA
involved in positive regulation of granzyme B production IDA
IDA: 通过直接分析推断
18832695 GOA
involved in positive regulation of interleukin-10 production IDA
IDA: 通过直接分析推断
18832695 GOA
involved in positive regulation of natural killer cell chemotaxis IDA
IDA: 通过直接分析推断
9029087 GOA
involved in positive regulation of release of sequestered calcium ion into cytosol IDA
IDA: 通过直接分析推断
7602097 GOA
involved in positive regulation of transforming growth factor beta production IDA
IDA: 通过直接分析推断
18832695 GOA
involved in regulation of inflammatory response IDA
IDA: 通过直接分析推断
18832695 GOA
involved in response to virus IDA
IDA: 通过直接分析推断
14734774 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

XCL1 蛋白结构

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (29 - 83)

  • 0
  • 100
  • 114 a.a.
蛋白主名 其他名称

lymphotactin

SCM-1-alpha

XCL1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
XCL1 P47992 PF4V1 Homo sapiens P10720 28381538
种属内
XCL1 P47992 PF4 Homo sapiens P02776 28381538
种属内
XCL1 P47992 PF4 Homo sapiens P02776
SPR
28381538
种属内
XCL1 P47992 CCL5 Homo sapiens P13501 28381538
种属内
XCL1 P47992 CCL5 Homo sapiens P13501
SPR
28381538
种属内
XCL1 P47992 CXCL12 Homo sapiens P48061
SPR
28381538
种属内
XCL1 P47992 CCL13 Homo sapiens Q99616 28381538
种属内
XCL1 P47992 CCL26 Homo sapiens Q9Y258 28381538
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 XCL1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7234 Lymphotactin/XCL1 Protein, Human P47992 (G23-G114) ≥95%
HY-P71434 Lymphotactin/XCL1 Protein, Human (HEK293, Fc-His) P47992 (V22-G114) ≥95%

关联疾病

疾病名称 别名
Sodoku Disease

Spirillosis

Sodoku

Spirillary Fever

Rat-Bite Fever

Rat-Bite Fever Due To Spirillum Minus

Spirillary Rat-Bite Fever

Sokosho

Renal Tuberculosis

Tuberculosis, Renal

Tuberculosis Of Kidney

Tuberculosis Renal

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus XCL1 RGD RGD:620452
Mus musculus XCL1 MGD MGI:104593
Canis familiaris XCL1 NCBI
Macaca fascicularis XCL1 NCBI NCBI:102131550
Susscrofa domestica XCL1 NCBI
Macaca mulatta XCL1 NCBI NCBI:574367