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  2. P2ry4 - pyrimidinergic receptor P2Y4 Gene

P2ry4 - pyrimidinergic receptor P2Y4 Gene

中文名称:嘧啶能受体P2 Y4

种属: Rattus norvegicus

同用名: P2Y4

基因 ID: 63843 | 基因类型: protein coding

关于 P2ry4

Primary_assembly X: 65,683,232-65,721,748 reverse strand.mRatBN7.2:CM026994.1

This gene has 4 transcripts (splice variants), 168 orthologues, 13 paralogues and is associated with 3 phenotypes. Biased expression in Adrenal (RPKM 16.9), Lung (RPKM 14.4) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 ATP 绑定活动。参与突触前细胞溶质钙离子浓度的调节和突触小泡胞吐作用的调节。位于顶端质膜和基底外侧质膜。在谷氨酸能突触中活跃。是突触前活动区膜的组成部分。与人 P2RY4(嘧啶能受体 P2Y4)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables ATP binding activity. Involved in regulation of presynaptic cytosolic calcium ion concentration and regulation of synaptic vesicle exocytosis. Located in apical plasma membrane and basolateral plasma membrane. Is active in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Orthologous to human P2RY4 (pyrimidinergic receptor P2Y4). [provided by Alliance of Genome Resources, Apr 2022]

P2ry4 基因产物(1)

mRNA Protein Name
NM_031680.1 NP_113868.1 P2Y purinoceptor 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
11557527 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
11557527 RGD
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
11557527 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
16000618 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
16000618 RGD
is active in presynaptic active zone membrane IDA
IDA: 通过直接分析推断
16000618 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

P2ry4 蛋白结构

7tmA_P2Y4

7tmA_P2Y4: cd15374 (31 - 312)

7tmA_P2Y4

7tmA_P2Y4: cd15374 (31 - 58)

7tmA_P2Y4

7tmA_P2Y4: cd15374 (65 - 90)

7tmA_P2Y4

7tmA_P2Y4: cd15374 (103 - 133)

7tmA_P2Y4

7tmA_P2Y4: cd15374 (145 - 167)

7tmA_P2Y4

7tmA_P2Y4: cd15374 (192 - 221)

7tmA_P2Y4

7tmA_P2Y4: cd15374 (233 - 263)

7tmA_P2Y4

7tmA_P2Y4: cd15374 (280 - 305)

  • 0
  • 100
  • 200
  • 300
  • 361 a.a.
蛋白主名 其他名称

P2Y purinoceptor 4

P2Y ATP receptor 4

purinergic receptor P2Y, G-protein coupled 4

pyrimidinergic receptor P2Y, G-protein coupled, 4

直系同源

种属 基因名 来源 基因 ID
Homo sapiens P2ry4 NCBI NCBI:5030