CHST8 - carbohydrate sulfotransferase 8 Gene

中文名称：碳水化合物磺基转移酶 8

种属: Homo sapiens

同用名: PSS3; GalNAc4ST; GALNAC4ST1

关于 CHST8

功能概要

该基因编码的蛋白质属于磺基转移酶 2 家族。它主要在垂体中表达，并定位于高尔基体膜。该蛋白质催化硫酸盐转移到 N-聚糖和 O-聚糖中非还原性 N-乙酰半乳糖胺 (GalNAc) 残基的第 4 位。它负责 GalNAc 对黄体生成素 (LH) 的硫酸化，黄体生成素是产生性激素所必需的。缺乏这种酶的小鼠表现出循环 LH 水平升高，以及雄性和雌性小鼠性早熟。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2011 年 8 月]

The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex Hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]