2. Gene
  3. CEP85 - centrosomal protein 85 Gene

CEP85 - centrosomal protein 85 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：中心体蛋白 85

种属: Homo sapiens

同用名: CCDC21

基因 ID: 64793 | 基因类型: protein coding

关于 CEP85

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,234,200-26,278,808 (from NCBI)

This gene has 8 transcripts (splice variants), 208 orthologues and 1 paralogue. Broad expression in testis (RPKM 23.4), heart (RPKM 8.7) and 20 other tissues.

功能概要

该基因编码的蛋白质属于中心体相关蛋白质家族。中心体是动物细胞中的亚细胞器，起微管组织中心的作用，参与细胞周期进程。交替剪接导致多个转录本变体。[RefSeq 提供，2013 年 7 月]

This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

CEP85 基因产物(4)

mRNA Protein Name
NM_001281517.3 NP_001268446.1 centrosomal protein of 85 kDa isoform 2
NM_001281518.3 NP_001268447.1 centrosomal protein of 85 kDa isoform 3
NM_001319944.2 NP_001306873.1 centrosomal protein of 85 kDa isoform 4
NM_022778.5 NP_073615.2 centrosomal protein of 85 kDa isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IDA
IDA: 通过直接分析推断
29712910 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18985028 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell migration IMP
IMP: 通过突变表型推断
32107292 GOA
involved in centriole assembly IMP
IMP: 通过突变表型推断
29712910 GOA
involved in centriole replication IMP
IMP: 通过突变表型推断
29712910 GOA
involved in negative regulation of protein kinase activity IMP
IMP: 通过突变表型推断
26220856 GOA
involved in regulation of mitotic centrosome separation IMP
IMP: 通过突变表型推断
26220856 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell cortex IDA
IDA: 通过直接分析推断
32107292 GOA
located in centriole IDA
IDA: 通过直接分析推断
29712910 GOA
located in centrosome IDA
IDA: 通过直接分析推断
21399614 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
21399614 GOA
located in pericentriolar material IDA
IDA: 通过直接分析推断
26220856 GOA
located in spindle pole IDA
IDA: 通过直接分析推断
21399614 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

centrosomal protein of 85 kDa

centrosomal protein 85kDa

CEP85 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CEP85 Q6P2H3 TERF1 Homo sapiens P54274
Pull Down
21044950
种属间
CEP85 Q6P2H3 Q9WMX2-PRO_0000037548 Hepatitis C virus Q9WMX2-PRO_0000037548
Pull Down
18985028
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Visual Agnosia

Primary Visual Agnosia
Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02526 CEP85 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02527 CEP85L Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CEP85 VGNC VGNC:39140
Bos taurus CEP85 VGNC VGNC:27216
Mus musculus CEP85 MGD MGI:1917262
Macaca mulatta CEP85 VGNC VGNC:71096
Rattus norvegicus CEP85 RGD RGD:1311520
Felis catus CEP85 VGNC VGNC:60786
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z