2. Gene
  3. Gphn - gephyrin Gene

Gphn - gephyrin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Geph

基因 ID: 64845 | 基因类型: protein coding

关于 Gphn

功能概要

Enables several functions, including identical protein binding activity; molybdopterin adenylyltransferase activity; and molybdopterin molybdotransferase activity. Involved in establishment of protein localization; neurotransmitter receptor localization to postsynaptic specialization membrane; and synapse assembly. Acts upstream of or within Mo-molybdopterin cofactor biosynthetic process. Located in cytoplasm; inhibitory synapse; and postsynaptic specialization. Is extrinsic component of cytoplasmic side of plasma membrane. Is active in glycinergic synapse and postsynaptic specialization, intracellular component. Human ortholog(s) of this gene implicated in inherited metabolic disorder and molybdenum cofactor deficiency type C. Orthologous to human GPHN (gephyrin). [provided by Alliance of Genome Resources, Apr 2022]

Gphn 基因产物(1)

mRNA Protein Name
NM_022865.4 NP_074056.2 gephyrin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
14976213 RGD
enables molecular adaptor activity IDA
IDA: 通过直接分析推断
10844024 RGD
enables molybdopterin adenylyltransferase activity IDA
IDA: 通过直接分析推断
23163752 RGD
enables molybdopterin molybdotransferase activity IDA
IDA: 通过直接分析推断
23163752 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10607391 RGD
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
14976213 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Mo-molybdopterin cofactor biosynthetic process IDA
IDA: 通过直接分析推断
23163752 RGD
involved in establishment of protein localization IMP
IMP: 通过突变表型推断
19914352 RGD
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: 通过直接分析推断
8264797 RGD
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: 通过突变表型推断
8264797 RGD
involved in synapse assembly IEP
IEP: 通过表达模式推断
9130666 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in GABA-ergic synapse IDA
IDA: 通过直接分析推断
18315564 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
12684523 RGD
located in cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
12684523 RGD
is active in glycinergic synapse IDA
IDA: 通过直接分析推断
8264797 RGD
is active in glycinergic synapse IMP
IMP: 通过突变表型推断
8264797 RGD
located in inhibitory synapse IDA
IDA: 通过直接分析推断
18550748 RGD
located in postsynapse IDA
IDA: 通过直接分析推断
18315564 RGD
is active in postsynaptic specialization, intracellular component IDA
IDA: 通过直接分析推断
9714149 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

gephyrin

putative glycine receptor-tubulin linker protein

Gphn 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Gphn Q03555 Glrb Mus musculus P48168
ITC
21829170
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05638 GPHN Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gphn NCBI NCBI:10243
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