SLC4A3 - solute carrier family 4 member 3 Gene

中文名称：溶质载体家族 4 成员 3

种属: Homo sapiens

同用名: AE3; SLC2C; CAE3/BAE3

基因 ID: 6508 | 基因类型: protein coding

关于 SLC4A3

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:219,627,630-219,641,971 (from NCBI)

This gene has 9 transcripts (splice variants), 211 orthologues, 9 paralogues and is associated with 2 phenotypes. Biased expression in heart (RPKM 53.3), ovary (RPKM 25.3) and 5 other tissues.

功能概要

该基因编码的蛋白质是质膜阴离子交换蛋白。已在大脑、心脏、肾脏、小肠和肺中发现编码的蛋白质。[RefSeq 提供，2016 年 5 月]

The protein encoded by this gene is a plasma membrane anion exchange protein. The encoded protein has been found in brain, heart, kidney, small intestine, and lung. [provided by RefSeq, May 2016]

SLC4A3 基因产物(3)

mRNA	Protein	Name
NM_001326559.2	NP_001313488.2	anion exchange protein 3 isoform 2
NM_005070.4	NP_005061.3	anion exchange protein 3 isoform 1
NM_201574.3	NP_963868.3	anion exchange protein 3 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables bicarbonate transmembrane transporter activity	IMP IMP: 通过突变表型推断	29167417	GOA
enables chloride:bicarbonate antiporter activity	IDA IDA: 通过直接分析推断	7923606	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in bicarbonate transport	IMP IMP: 通过突变表型推断	29167417	GOA
acts upstream of or within cardiac conduction	IMP IMP: 通过突变表型推断	29167417	GOA
involved in pH reduction	IMP IMP: 通过突变表型推断	29167417	GOA
involved in regulation of cardiac muscle cell action potential	IMP IMP: 通过突变表型推断	29167417	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in external side of plasma membrane	IMP IMP: 通过突变表型推断	29167417	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	29167417	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC4A3 蛋白结构

Band_3_cyto

HCO3_cotransp

0
200
400
600
800
1000
1232 a.a.

蛋白主名

其他名称

anion exchange protein 3

Anion exchanger 3, neuronal

SLC4A3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SLC4A3	P48751	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
种属内	SLC4A3	P48751	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
种属内	SLC4A3	P48751	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Familial Short Qt Syndrome

Sqts	Genetic Short Qt Syndrome

Subvalvular Aortic Stenosis

Fixed Subaortic Stenosis	Subaortic Stenosis
Aortic Stenosis, Subvalvular

Cataract 14, Multiple Types

Cataract 14 Multiple Types	CTRCT14
Czp3	Cae3
Cataract, Zonular Pulverulent 3	Zonular Pulverulent Cataract 3
Cataract, Zonular Pulverulent-3	Cataract, Type 14, Multiple Types

Complex Partial Epilepsy

Epilepsy, Complex Partial	Complex Partial Epileptic Seizure
Epilepsy, Psychomotor	Psychomotor Epilepsy

Cone-Rod Dystrophy 1

CORD1	Crd1
Cone-Rod Retinal Dystrophy-1	Retinitis Pigmentosa 1

Brown-Vialetto-Van Laere Syndrome 2

BVVLS2	Rfvt3-Related Riboflavin Transporter Deficiency
Rtd3	Riboflavin Transporter Deficiency 3
Brown-Vialetto-Van Laere Syndrome, Type 2

Epilepsy, Idiopathic Generalized

Idiopathic Generalized Epilepsy	Generalised Epilepsy
Epilepsy, Generalized	EIG
Ige	Epilepsy, Idiopathic Generalized, Susceptibility To, 1
Epilepsy, Idiopathic Generalized 1	Epilepsy, Idiopathic Generalized, Susceptibility To
Epilepsy, Idiopathic, Generalized	Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1

Hereditary Elliptocytosis

Congenital Elliptocytosis	Ovalocytosis
Elliptocytosis, Hereditary	He
Elliptocytosis Hereditary	Congenital Ovalocytosis
Elliptocytosis	Hereditary Elliptocytosis With Infantile Poikilocytosis
Hereditary Ovalocytosis	Oval Erythrocytosis
He - [Hereditary Elliptocytosis]	Elliptocytosis Anaemia

Familial Febrile Seizures

Familial Febrile Convulsions	Feb
Febrile Seizures, Familial

Late-Onset Retinal Degeneration

LORD	Retinal Degeneration, Late-Onset, Autosomal Dominant
Autosomal Dominant Late-Onset Retinal Degeneration	Pigmentary Retinopathy
Retinal Degeneration, Late-Onset	Retinitis Pigmentosa

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Leber Plus Disease

Leber Congenital Amaurosis	Lca
Leber'S Amaurosis	Leber'S Disease
Amaurosis Congenita Of Leber	Amaurosis Congenita Of Leber, Type 1
Lhon Plus Disease	Congenital Absence Of The Rods And Cones
Congenital Retinal Blindness	Crb
Congenital Amaurosis Of Retinal Origin	Leber'S Congenital Amaurosis
Leber Congenital Amaurosis 1	Leber'S Congenital Tapetoretinal Degeneration
Leber'S Congenital Tapetoretinal Dysplasia	Lca1
Leber Congenital Amaurosis Type 1	Retinal Blindness, Congenital
Amaurosis, Leber Congenital	Dysgenesis Neuroepithelialis Retinae
Hereditary Epithelial Dysplasia Of Retina	Hereditary Retinal Aplasia
Heredoretinopathia Congenitalis	Leber Abiotrophy
Leber Congenital Tapetoretinal Degeneration	Lebers Congenital Amaurosis
Optic Atrophy, Hereditary, Leber

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13269	SLC4A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	SLC4A3	MGD	MGI:109350
Canis familiaris	SLC4A3	VGNC	VGNC:46433
Bos taurus	SLC4A3	VGNC	VGNC:34893
Macaca mulatta	SLC4A3	VGNC	VGNC:77604
Felis catus	SLC4A3	VGNC	VGNC:65388
Rattus norvegicus	SLC4A3	RGD	RGD:3712

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLC4A3 - solute carrier family 4 member 3 Gene

关于 SLC4A3

功能概要

SLC4A3 基因产物(3)

SLC4A3 蛋白结构

SLC4A3 蛋白互作信息

关联疾病

直系同源

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SLC4A3 - solute carrier family 4 member 3 Gene

关于 SLC4A3

功能概要

SLC4A3 基因产物(3)

SLC4A3 蛋白结构

SLC4A3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z