2. Gene
  3. Agap2 - ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 Gene

Agap2 - ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Pike; Centg1

基因 ID: 65218 | 基因类型: protein coding

关于 Agap2

功能概要

Enables protein kinase activator activity and protein kinase binding activity. Involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of neuron apoptotic process; and positive regulation of phosphatidylinositol 3-kinase signaling. Located in nucleus. Human ortholog(s) of this gene implicated in prostate Cancer. Orthologous to human AGAP2 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 2). [provided by Alliance of Genome Resources, Apr 2022]

Agap2 基因产物(1)

mRNA Protein Name
NM_023026.2 NP_075415.2 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ionotropic glutamate receptor binding IPI
IPI: 通过物理相互作用推断
21847098 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
14528310 RGD
enables protein kinase activator activity IDA
IDA: 通过直接分析推断
11136977 RGD
enables protein kinase binding IDA
IDA: 通过直接分析推断
11136977 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
21847098 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to glycine IDA
IDA: 通过直接分析推断
21847098 RGD
involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: 通过突变表型推断
18469807 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
14528310 RGD
involved in phosphatidylinositol metabolic process IMP
IMP: 通过突变表型推断
21847098 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
14528310 RGD
involved in positive regulation of protein localization to cell surface IMP
IMP: 通过突变表型推断
21847098 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite IDA
IDA: 通过直接分析推断
21847098 RGD
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
21847098 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

AGAP-2

centaurin, gamma 1

cnt-g1

nuclear GTPase PIKE

phosphatidylinositol 3-kinase enhancer

Agap2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Agap2 Q8CGU4 UNC5B Homo sapiens Q8IZJ1
Y2H
18469807
种属间
Agap2 Q8CGU4 UNC5B Homo sapiens Q8IZJ1
Anti Bait CoIP
18469807
种属间
Agap2 Q8CGU4 UNC5B Homo sapiens Q8IZJ1
Anti Tag CoIP
18469807
种属内
Agap2 Q8CGU4 Gria2 Rattus norvegicus P19491
Anti Bait CoIP
21847098
种属内
Agap2 Q8CGU4 Grip1 Rattus norvegicus P97879
Anti Bait CoIP
21847098
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00438 AGAP2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Agap2 NCBI NCBI:116986
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