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  3. AACS - acetoacetyl-CoA synthetase Gene

AACS - acetoacetyl-CoA synthetase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：乙酰乙酰辅酶 A 合成酶

种属: Homo sapiens

同用名: ACSF1; SUR-5

基因 ID: 65985 | 基因类型: protein coding

关于 AACS

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:125,065,435-125,143,316 (from NCBI)

This gene has 12 transcripts (splice variants), 201 orthologues and 13 paralogues. Ubiquitous expression in fat (RPKM 23.3), skin (RPKM 16.5) and 24 other tissues.

功能概要

预测启用乙酰乙酸-CoA 连接酶活性。预计参与胰岛素分泌的正调节。预计在胞质溶胶中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable acetoacetate-CoA ligase activity. Predicted to be involved in positive regulation of Insulin secretion. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

AACS 基因产物(7)

mRNA Protein Name
NM_001319839.2 NP_001306768.1 acetoacetyl-CoA synthetase isoform 2
NM_001319840.2 NP_001306769.1 acetoacetyl-CoA synthetase isoform 3
NM_001414675.1 NP_001401604.1 acetoacetyl-CoA synthetase isoform 4
NM_001414676.1 NP_001401605.1 acetoacetyl-CoA synthetase isoform 5
NM_001414677.1 NP_001401606.1 acetoacetyl-CoA synthetase isoform 6
NM_001414678.1 NP_001401607.1 acetoacetyl-CoA synthetase isoform 7
NM_023928.5 NP_076417.2 acetoacetyl-CoA synthetase isoform 1

AACS 蛋白结构

AMP-binding

AMP-binding: AMP-binding enzyme (109 - 544)

  • 0
  • 200
  • 400
  • 600
  • 672 a.a.
蛋白主名 其他名称

acetoacetyl-CoA synthetase

acetoacetate-CoA ligase

重组 AACS 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74435 AACS Protein, Human (sf9, His) Q86V21 (M1-F672) ≥95%

关联疾病

疾病名称 别名
Atrial Septal Defect 8

ASD8

Atrial Heart Septal Defect 8

Septal Defect, Atrial, Type 8
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0124 Zonisamide Inhibitor 99.94% 是
HY-B0124A Zonisamide sodium Inhibitor / 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-14880B Bavisant dihydrochloride hydrate Antagonist 99.26% Phase 2
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00016 AACS Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris AACS VGNC VGNC:37403
Mus musculus AACS MGD MGI:1926144
Rattus norvegicus AACS RGD RGD:708522
Felis catus AACS VGNC VGNC:59448
Bos taurus AACS VGNC VGNC:25438
Macaca mulatta AACS VGNC VGNC:97730
Others AACS NCBI
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