2. Gene
  3. Mcub - mitochondrial calcium uniporter dominant negative beta subunit Gene

Mcub - mitochondrial calcium uniporter dominant negative beta subunit Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ccdc109b; 9030408N13Rik

基因 ID: 66815 | 基因类型: protein coding

关于 Mcub

功能概要

Enables Calcium Channel Inhibitor activity. Involved in mitochondrial calcium ion homeostasis and mitochondrial calcium ion transmembrane transport. Located in mitochondrion. Is intrinsic component of membrane. Part of Calcium Channel complex. Orthologous to human MCUB (mitochondrial calcium uniporter dominant negative subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Mcub 基因产物(2)

mRNA Protein Name
NM_001293644.2 NP_001280573.2 calcium uniporter regulatory subunit MCUb, mitochondrial isoform 2
NM_025779.4 NP_080055.3 calcium uniporter regulatory subunit MCUb, mitochondrial isoform1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium channel inhibitor activity IDA
IDA: 通过直接分析推断
23900286 MGI
NOT enables monoatomic ion channel activity IDA
IDA: 通过直接分析推断
23900286 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
23900286 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mitochondrial calcium ion homeostasis IMP
IMP: 通过突变表型推断
23900286 MGI
involved in mitochondrial calcium ion transmembrane transport IMP
IMP: 通过突变表型推断
23900286 MGI
involved in negative regulation of calcium import into the mitochondrion IDA
IDA: 通过直接分析推断
31533452 MGI
involved in positive regulation of skeletal muscle satellite cell differentiation IMP
IMP: 通过突变表型推断
34726954 MGI
involved in regulation of macrophage activation IMP
IMP: 通过突变表型推断
34726954 MGI
involved in skeletal muscle tissue regeneration IMP
IMP: 通过突变表型推断
34726954 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of calcium channel complex IDA
IDA: 通过直接分析推断
23900286 MGI
located in membrane IDA
IDA: 通过直接分析推断
23900286 MGI
located in mitochondrion IMP
IMP: 通过突变表型推断
23900286 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

calcium uniporter regulatory subunit MCUb, mitochondrial

coiled-coil domain containing 109B

coiled-coil domain-containing protein 109B

mitochondrial calcium uniporter regulatory subunit MCUb

Mcub 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Mcub Q810S1 Mcu Mus musculus Q3UMR5
Anti Tag CoIP
23900286
种属内
Mcub Q810S1 Mcu Mus musculus Q3UMR5
FRET
23900286
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08253 MCUB Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17019 Areg Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20771 Mcub Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27285 Mcub Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mcub NCBI NCBI:55013
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