2. Gene
  3. ZFP36L2 - ZFP36 ring finger protein like 2 Gene

ZFP36L2 - ZFP36 ring finger protein like 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ZFP36 无名指蛋白样 2

种属: Homo sapiens

同用名: BRF2; ERF2; ERF-2; OOMD13; TIS11D; RNF162C

基因 ID: 678 | 基因类型: protein coding

关于 ZFP36L2

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:43,222,402-43,226,606 (from NCBI)

This gene has 1 transcript (splice variant), 206 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 108.0), appendix (RPKM 94.7) and 25 other tissues.

功能概要

该基因是早期反应基因 TIS11 家族的成员。家族成员由各种激动剂诱导，例如佛波醇酯 TPA 和多肽有丝分裂原 EGF。编码的蛋白质包含一个有区别的推定锌指结构域和一个重复的 cys-his 基序。这种推定的核转录因子最有可能在调节对生长因子的反应中发挥作用。[RefSeq 提供，2008 年 7 月]

This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]

ZFP36L2 基因产物(1)

mRNA Protein Name
NM_006887.5 NP_008818.3 mRNA decay activator protein ZFP36L2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables mRNA 3'-UTR AU-rich region binding IDA
IDA: 通过直接分析推断
20506496 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25106868 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 3'-UTR-mediated mRNA destabilization IMP
IMP: 通过突变表型推断
25106868 GOA
involved in ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
25106868 GOA
involved in cellular response to epidermal growth factor stimulus IDA
IDA: 通过直接分析推断
20166898 GOA
involved in cellular response to fibroblast growth factor stimulus IDA
IDA: 通过直接分析推断
20166898 GOA
involved in cellular response to glucocorticoid stimulus IDA
IDA: 通过直接分析推断
20166898 GOA
involved in cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
IDA: 通过直接分析推断
20166898 GOA
involved in cellular response to transforming growth factor beta stimulus IDA
IDA: 通过直接分析推断
20166898 GOA
involved in cellular response to tumor necrosis factor IDA
IDA: 通过直接分析推断
20166898 GOA
involved in mRNA catabolic process IMP
IMP: 通过突变表型推断
34611029 GOA
involved in regulation of mRNA stability IMP
IMP: 通过突变表型推断
25106868 GOA
involved in response to wounding IDA
IDA: 通过直接分析推断
27182009 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZFP36L2 蛋白结构

Tis11B_N

Tis11B_N: Tis11B like protein, N terminus (1 - 144)

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (154 - 180)

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (192 - 217)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 494 a.a.
蛋白主名 其他名称

mRNA decay activator protein ZFP36L2

EGF-response factor 2

ZFP36L2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZFP36L2 P47974 YWHAE Homo sapiens P62258
Crosslink
36931259
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Achromatopsia 7

ACHM7

Achromatopsia, Type 7
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16042 ZFP36L2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20661 Zfp36l2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27172 Zfp36l2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ZFP36L2 RGD RGD:1308913
Macaca mulatta ZFP36L2 VGNC VGNC:106246
Bos taurus ZFP36L2 VGNC VGNC:54514
Canis familiaris ZFP36L2 VGNC VGNC:48614
Mus musculus ZFP36L2 MGD MGI:107945
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z