2. Gene
  3. Atg3 - autophagy related 3 Gene

Atg3 - autophagy related 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: APG3; Apg3l; Atg3l; PC3-96; 2610016C12Rik

基因 ID: 67841 | 基因类型: protein coding

关于 Atg3

功能概要

Enables Atg12 transferase activity and Atg8 Ligase activity. Involved in autophagosome assembly; mitochondrial fragmentation involved in apoptotic process; and regulation of cilium assembly. Acts upstream of or within macroautophagy and negative regulation of phagocytosis. Predicted to be located in cytoplasm. Predicted to be part of cytoplasmic ubiquitin Ligase complex. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human ATG3 (Autophagy related 3). [provided by Alliance of Genome Resources, Apr 2022]

Atg3 基因产物(2)

mRNA Protein Name
NM_001356366.1 NP_001343295.1 ubiquitin-like-conjugating enzyme ATG3 isoform 2
NM_026402.3 NP_080678.1 ubiquitin-like-conjugating enzyme ATG3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Atg12 transferase activity IDA
IDA: 通过直接分析推断
20723759 MGI
enables Atg8-family ligase activity IMP
IMP: 通过突变表型推断
20723759 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
18321988 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in autophagosome assembly IDA
IDA: 通过直接分析推断
24747438 MGI
acts upstream of or within autophagosome assembly IMP
IMP: 通过突变表型推断
21220506 MGI
involved in autophagosome assembly IMP
IMP: 通过突变表型推断
20723759 MGI
involved in autophagy IMP
IMP: 通过突变表型推断
18768753 MGI
acts upstream of or within macroautophagy IMP
IMP: 通过突变表型推断
24035364 MGI
involved in mitochondrial fragmentation involved in apoptotic process IMP
IMP: 通过突变表型推断
20723759 MGI
acts upstream of or within negative regulation of phagocytosis IMP
IMP: 通过突变表型推断
24035364 MGI
involved in regulation of cilium assembly IMP
IMP: 通过突变表型推断
24089205 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ubiquitin-like-conjugating enzyme ATG3

autophagy-related protein 3

Atg3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Atg3 Q9CPX6 Atg12 Mus musculus Q9CQY1
Anti Tag CoIP
20723759
种属内
Atg3 Q9CPX6 Atg12 Mus musculus Q9CQY1
Anti Tag CoIP
25686249
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-156966 ATG12-ATG3 inhibitor 1 Inhibitor 99.31% 否
HY-162932 ATG12-IN-1 Inhibitor / 否
HY-RS01147 ATG3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18909 Atg3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25400 Atg3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Atg3 NCBI NCBI:64422
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