2. Gene
  3. Rtn4 - reticulon 4 Gene

Rtn4 - reticulon 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: ASY; NgA; NOGO; NSP-CL; Nogo-A; Nogo-B; Nogo-C; mKIAA0886; mKIAA4153; 1110020G17Rik; C130026I10Rik

基因 ID: 68585 | 基因类型: protein coding

关于 Rtn4

功能概要

Predicted to enable Cadherin binding activity; protein homodimerization activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including neurogenesis; positive regulation of leukocyte migration; and vasculogenesis. Acts upstream of or within blastocyst formation; circulatory system development; and regulation of cell growth. Located in several cellular components, including dendritic growth cone; neuronal cell body; and postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; limb mesenchyme; sensory organ; and skeletal musculature. Orthologous to human RTN4 (reticulon 4). [provided by Alliance of Genome Resources, Apr 2022]

Rtn4 基因产物(5)

mRNA Protein Name
NM_024226.4 NP_077188.1 reticulon-4 isoform C
NM_194051.3 NP_918940.1 reticulon-4 isoform D
NM_194052.3 NP_918941.1 reticulon-4 isoform B1
NM_194053.3 NP_918942.1 reticulon-4 isoform B2
NM_194054.3 NP_918943.1 reticulon-4 isoform A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11201742 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in axonal fasciculation IMP
IMP: 通过突变表型推断
20573699 MGI
acts upstream of or within blastocyst formation IMP
IMP: 通过突变表型推断
27869233 MGI
acts upstream of or within cardiac epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
19156209 MGI
involved in cell migration involved in vasculogenesis IMP
IMP: 通过突变表型推断
23625008 MGI
involved in cellular response to hypoxia IDA
IDA: 通过直接分析推断
27763637 MGI
involved in central nervous system vasculogenesis IMP
IMP: 通过突变表型推断
23625008 MGI
involved in cerebral cortex radial glia-guided migration IMP
IMP: 通过突变表型推断
20093372 MGI
involved in intracellular sphingolipid homeostasis IMP
IMP: 通过突变表型推断
26301690 MGI
involved in leukocyte migration involved in inflammatory response IMP
IMP: 通过突变表型推断
21183689 MGI
involved in modulation of chemical synaptic transmission EXP
EXP: 通过实验结果推断
30040841 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
30040841 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
30040841 MGI
involved in negative regulation of axon extension IMP
IMP: 通过突变表型推断
20573699 MGI
involved in negative regulation of vasculogenesis IMP
IMP: 通过突变表型推断
23625008 MGI
acts upstream of or within nervous system development IDA
IDA: 通过直接分析推断
12225863 MGI
involved in positive regulation of Rac protein signal transduction IMP
IMP: 通过突变表型推断
19805174 MGI
involved in positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
19805174 MGI
involved in positive regulation of artery morphogenesis IMP
IMP: 通过突变表型推断
19805174 MGI
involved in positive regulation of hepatocyte proliferation IMP
IMP: 通过突变表型推断
23299899 MGI
involved in positive regulation of macrophage cytokine production IMP
IMP: 通过突变表型推断
19805174 MGI
involved in positive regulation of macrophage migration IMP
IMP: 通过突变表型推断
19805174 MGI
involved in positive regulation of neutrophil migration IMP
IMP: 通过突变表型推断
21183689 MGI
involved in positive regulation of toll-like receptor 9 signaling pathway IMP
IMP: 通过突变表型推断
25917084 MGI
involved in protein localization to lysosome IMP
IMP: 通过突变表型推断
25917084 MGI
involved in protein stabilization IMP
IMP: 通过突变表型推断
27353365 MGI
involved in regulation of branching morphogenesis of a nerve IMP
IMP: 通过突变表型推断
20573699 MGI
involved in regulation of nervous system development IMP
IMP: 通过突变表型推断
20573699 MGI
involved in regulation of postsynapse assembly EXP
EXP: 通过实验结果推断
26748478 MGI
involved in regulation of postsynapse assembly IDA
IDA: 通过直接分析推断
26748478 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell projection IDA
IDA: 通过直接分析推断
15121177 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
12225863 MGI
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
26301690 MGI
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
26748478 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
26748478 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
30040841 MGI
is active in postsynapse IDA
IDA: 通过直接分析推断
30040841 MGI
is active in postsynapse IMP
IMP: 通过突变表型推断
30040841 MGI
located in postsynaptic density IDA
IDA: 通过直接分析推断
17114649 MGI
located in synapse IDA
IDA: 通过直接分析推断
35771867 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

reticulon-4

neurite outgrowth inhibitor

Rtn4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Rtn4 Q99P72 Hspa4l Mus musculus P48722
Anti Bait CoIP
23909438
种属内
Rtn4 Q99P72 Hspa4l Mus musculus P48722
PLA
23909438
种属内
Rtn4 Q99P72 Hspa4l Mus musculus P48722
Confocal
23909438
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12332 RTN4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS12333 RTN4IP1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS12334 RTN4R Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS12335 RTN4RL1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18682 Rtn4r Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18788 Rtn4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20640 Rtn4rl1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25168 Rtn4r Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25277 Rtn4 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27150 Rtn4rl1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rtn4 NCBI NCBI:57142
Macaca fascicularis Rtn4 NCBI NCBI:101865007
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