2. Gene
  3. TACR2 - tachykinin receptor 2 Gene

TACR2 - tachykinin receptor 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：速激肽受体 2

种属: Homo sapiens

同用名: SKR; NK2R; NKNAR; TAC2R

基因 ID: 6865 | 基因类型: protein coding

关于 TACR2

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:69,403,903-69,416,918 (from NCBI)

This gene has 2 transcripts (splice variants), 200 orthologues and 33 paralogues. Biased expression in esophagus (RPKM 8.8), endometrium (RPKM 7.3) and 9 other tissues.

功能概要

该基因属于作为速激肽受体发挥作用的基因家族。受体亲和力由序列 5' 端的变化指定。属于该家族的受体的特征在于与 G 蛋白和 7 个疏水跨膜区域的相互作用。该基因编码速激肽神经肽物质 K 的受体，也称为神经激肽 A。[RefSeq 提供，2008 年 7 月]

This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]

TACR2 基因产物(1)

mRNA Protein Name
NM_001057.3 NP_001048.2 substance-K receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12716968 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of flagellated sperm motility IMP
IMP: 通过突变表型推断
17437961 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in sperm flagellum IDA
IDA: 通过直接分析推断
17437961 GOA
located in sperm head IDA
IDA: 通过直接分析推断
17437961 GOA
located in sperm midpiece IDA
IDA: 通过直接分析推断
17437961 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TACR2 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (50 - 307)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
蛋白主名 其他名称

substance-K receptor

NK-2 receptor

NK-2R

neurokinin 2 receptor

neurokinin A receptor

neurokinin B receptor

seven transmembrane helix receptor

TACR2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TACR2 P21452 P20366-PRO_0000033534 Homo sapiens P20366-PRO_0000033534
SPA
23597562
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Occupational Asthma
Capillary Malformations, Congenital

Familial Multiple Nevi Flammei

Nevi Flammei, Familial Multiple

CMC

Port-Wine Stain

Capillary Malformations

Cmal

Familial Multiple Port-Wine Stains

Capillary Malformation

Capillary Malformations, Congenital, 1, Somatic, Mosaic

Congenital Capillary Malformations

Port-Wine Stain Familial Multiple

Hereditary Capillary Malformations

Capillary Malformations, Hereditary

Capillary Malformations, Congenital, Type 1, Somatic, Mosaic

Strawberry Nevus Of Skin

Naevus Flammeus
Posterior Cerebral Artery Infarction

Infarction, Posterior Cerebral Artery
Baritosis

Deposition Of Barium In The Lungs

Inhalation Of Barytes
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Environmental Induced Asthma

Irritant Asthma
Constipation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P3848 Tyr0-Neurokinin A Agonist / 否
HY-RS14146 TACR2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS14147 Tacr2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS14148 Tacr2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TACR2 VGNC VGNC:78084
Bos taurus TACR2 VGNC VGNC:35561
Rattus norvegicus TACR2 RGD RGD:3812
Canis familiaris TACR2 VGNC VGNC:47067
Mus musculus TACR2 MGD MGI:98477
Felis catus TACR2 VGNC VGNC:65921
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