2. Gene
  3. Eif4a3 - eukaryotic translation initiation factor 4A3 Gene

Eif4a3 - eukaryotic translation initiation factor 4A3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: eIF4A-III

基因 ID: 688288 | 基因类型: protein coding

关于 Eif4a3

功能概要

Enables RNA binding activity; ribonucleoprotein complex binding activity; and translation regulator activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; cellular response to selenite ion; and regulation of translation. Located in several cellular components, including dendrite; neuronal cell body; and nucleus. Part of ribonucleoprotein complex. Is active in glutamatergic synapse and postsynaptic cytosol. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human EIF4A3 (eukaryotic translation initiation factor 4A3). [provided by Alliance of Genome Resources, Apr 2022]

Eif4a3 基因产物(1)

mRNA Protein Name
NM_001100158.2 NP_001093628.1 eukaryotic initiation factor 4A-III
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA stem-loop binding IDA
IDA: 通过直接分析推断
21685449 RGD
enables ribonucleoprotein complex binding IDA
IDA: 通过直接分析推断
17632064 RGD
enables selenocysteine insertion sequence binding IDA
IDA: 通过直接分析推断
21685449 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in associative learning IEP
IEP: 通过表达模式推断
22982623 RGD
involved in cellular response to brain-derived neurotrophic factor stimulus IEP
IEP: 通过表达模式推断
17632064 RGD
involved in cellular response to selenite ion IEP
IEP: 通过表达模式推断
19716792 RGD
involved in exploration behavior IEP
IEP: 通过表达模式推断
22982623 RGD
involved in negative regulation of excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
17632064 RGD
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
17632064 RGD
involved in negative regulation of selenocysteine incorporation IDA
IDA: 通过直接分析推断
19716792 RGD
involved in regulation of translation at postsynapse, modulating synaptic transmission IDA
IDA: 通过直接分析推断
17632064 RGD
involved in regulation of translation at postsynapse, modulating synaptic transmission IMP
IMP: 通过突变表型推断
17632064 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
17632064 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite IDA
IDA: 通过直接分析推断
17632064 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
17632064 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
17632064 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
17632064 RGD
part of ribonucleoprotein complex IDA
IDA: 通过直接分析推断
17632064 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

eukaryotic initiation factor 4A-III

ATP-dependent RNA helicase DDX48

ATP-dependent RNA helicase eIF4A-3

DEAD box protein 48

eIF-4A-III

相关产品

Pre-clinical Phase
生物活性分子 (25)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101513 eIF4A3-IN-1 Inhibitor 99.96% 否
HY-101785 eIF4A3-IN-2 Inhibitor 99.70% 否
HY-33838 eIF4A3-IN-8 Inhibitor 99.98% 否
HY-148446 eIF4A3-IN-12 Inhibitor 99.70% 否
HY-148450 eIF4A3-IN-16 Inhibitor 98.37% 否
HY-43913 (R)-eIF4A3-IN-2 ≥95.0% 否
HY-148452 eIF4A3-IN-18 Inhibitor 99.58% 否
HY-139872 eIF4A3-IN-4 Inhibitor 99.8% 否
HY-145309 eIF4E-IN-3 Inhibitor / 否
HY-148443 eIF4A3-IN-9 Inhibitor 99.71% 否
HY-148444 eIF4A3-IN-10 Inhibitor 97.87% 否
HY-148445 eIF4A3-IN-11 Inhibitor 99.24% 否
HY-148447 eIF4A3-IN-13 Inhibitor 99.92% 否
HY-148448 eIF4A3-IN-14 Inhibitor 99.81% 否
HY-148449 eIF4A3-IN-15 Inhibitor / 否
HY-148451 eIF4A3-IN-17 Inhibitor 99.56% 否
HY-145359 eIF4A3-IN-5 Inhibitor / 否
HY-145360 eIF4A3-IN-6 Inhibitor / 否
HY-145361 eIF4A3-IN-7 Inhibitor / 否
HY-RS04272 EIF4A3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS04276 EIF4E3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS04279 EIF4EBP3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS04283 EIF4G3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17850 Eif4a3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24318 Eif4a3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Eif4a3 NCBI NCBI:9775
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