1. Cell Cycle/DNA Damage
  2. Eukaryotic Initiation Factor (eIF)
  3. eIF4A3-IN-14

eIF4A3-IN-14 (compound 51) 是 silvestrol (HY-13251) 类似物。eIF4A3-IN-14 干扰 eIF4F 翻译复合体组装,对 myc-LUC 和抑制 MBA-MB-231 细胞生长的 EC50 值分别为 40 和 50 nM。eIF4A3-IN-14 可用于人类肿瘤发病机制的研究。

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eIF4A3-IN-14 Chemical Structure

eIF4A3-IN-14 Chemical Structure

CAS No. : 1402931-65-0

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

eIF4A3-IN-14 (compound 51) is a silvestrol (HY-13251) analogue. eIF4A3-IN-14 interferes the assembling of eIF4F translation complex with EC50s of 40 and 50 nM for myc-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-14 can be used for the research of human cancer pathogenesis[1].

分子量

477.51

Formula

C27H27NO7

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
eIF4A3-IN-14
目录号:
HY-148448
需求量: