TGFBR3 - transforming growth factor beta receptor 3 Gene

中文名称：转化生长因子β受体 3

种属: Homo sapiens

同用名: BGCAN; betaglycan

基因 ID: 7049 | 基因类型: protein coding

关于 TGFBR3

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:91,680,343-91,906,002 (from NCBI)

This gene has 11 transcripts (splice variants), 203 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 40.0), ovary (RPKM 37.4) and 23 other tissues.

功能概要

该基因座编码转化生长因子 (TGF) -β III 型受体。编码的受体是一种膜蛋白多糖，通常与其他 TGF-β 受体超家族成员一起作为共同受体发挥作用。胞外域脱落产生可溶性 TGFBR3，这可能会抑制 TGFB 信号传导。已在多种癌症中观察到该受体的表达降低。已为该基因鉴定出编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2010 年 9 月]

This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta Receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]

TGFBR3 基因产物(12)

mRNA	Protein	Name
XM_047429271.1	XP_047285227.1	transforming growth factor beta receptor type 3 isoform X2
XM_047429254.1	XP_047285210.1	transforming growth factor beta receptor type 3 isoform X1
NM_001195683.2	NP_001182612.1	transforming growth factor beta receptor type 3 isoform b precursor
XM_047429255.1	XP_047285211.1	transforming growth factor beta receptor type 3 isoform X1
NM_001195684.1	NP_001182613.1	transforming growth factor beta receptor type 3 isoform b precursor
NR_036634.2
XM_047429256.1	XP_047285212.1	transforming growth factor beta receptor type 3 isoform X2
XM_047429247.1	XP_047285203.1	transforming growth factor beta receptor type 3 isoform X1
XM_006710867.3	XP_006710930.1	transforming growth factor beta receptor type 3 isoform X1
XM_047429261.1	XP_047285217.1	transforming growth factor beta receptor type 3 isoform X2
XM_047429273.1	XP_047285229.1	transforming growth factor beta receptor type 3 isoform X3
NM_003243.5	NP_003234.2	transforming growth factor beta receptor type 3 isoform a precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables BMP binding	IPI IPI: 通过物理相互作用推断	18184661	GOA
enables SMAD binding	IMP IMP: 通过突变表型推断	11157754	GOA
enables coreceptor activity	IDA IDA: 通过直接分析推断	10746731	GOA
contributes to protein binding	IPI IPI: 通过物理相互作用推断	10746731	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10746731	GOA
enables transforming growth factor beta binding	IDA IDA: 通过直接分析推断	11157754	GOA
contributes to transforming growth factor beta binding	IPI IPI: 通过物理相互作用推断	11157754	GOA
enables transforming growth factor beta receptor activity	IDA IDA: 通过直接分析推断	12958365	GOA
enables transforming growth factor beta receptor activity, type III	IDA IDA: 通过直接分析推断	10746731	GOA
enables transmembrane signaling receptor activity	IDA IDA: 通过直接分析推断	18184661	GOA
enables type II transforming growth factor beta receptor binding	IDA IDA: 通过直接分析推断	11157754	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in BMP signaling pathway	IDA IDA: 通过直接分析推断	18184661	GOA
involved in cardiac epithelial to mesenchymal transition	IDA IDA: 通过直接分析推断	18184661	GOA
involved in epithelial to mesenchymal transition	IDA IDA: 通过直接分析推断	18184661	GOA
involved in immune response	IMP IMP: 通过突变表型推断	16886151	GOA
involved in intracellular signal transduction	IMP IMP: 通过突变表型推断	14557487	GOA
involved in negative regulation of SMAD protein signal transduction	IMP IMP: 通过突变表型推断	30729664	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: 通过直接分析推断	29130787	GOA
involved in negative regulation of cell migration	IDA IDA: 通过直接分析推断	29130787	GOA
involved in negative regulation of extracellular matrix assembly	IMP IMP: 通过突变表型推断	30729664	GOA
involved in positive regulation of SMAD protein signal transduction	IDA IDA: 通过直接分析推断	18184661	GOA
involved in positive regulation of SMAD protein signal transduction	IMP IMP: 通过突变表型推断	11157754	GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis	IMP IMP: 通过突变表型推断	30467960	GOA
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	30467960	GOA
involved in response to follicle-stimulating hormone	IDA IDA: 通过直接分析推断	14557487	GOA
involved in response to luteinizing hormone	IDA IDA: 通过直接分析推断	14557487	GOA
involved in response to prostaglandin E	IDA IDA: 通过直接分析推断	14557487	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: 通过直接分析推断	12958365	GOA
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: 通过突变表型推断	11157754	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in external side of plasma membrane	IDA IDA: 通过直接分析推断	12958365	GOA
part of inhibin-betaglycan-ActRII complex	IDA IDA: 通过直接分析推断	10746731	GOA
part of receptor complex	IDA IDA: 通过直接分析推断	11157754	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TGFBR3 蛋白结构

Zona_pellucida

0
200
400
600
800
851 a.a.

蛋白主名

其他名称

transforming growth factor beta receptor type 3

TGF-beta receptor type 3	TGF-beta receptor type III
TGFR-3	betaglycan proteoglycan
transforming growth factor beta receptor III

TGFBR3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TGFBR3	Q03167	GIPC1	Homo sapiens	O14908	Pull Down	11546783
种属内	TGFBR3	Q03167	GIPC1	Homo sapiens	O14908	Y2H Array	11546783

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TGFBR3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P74521	TGFBR3/TGF-beta RIII Protein, Human (sf9, His)	Q03167 (G21-G781)	≥95%

TGFBR3 抗体

目录号	产品名	应用	反应物种
HY-P84476	TGFBR3 Antibody (YA4173)	WB, ELISA	Human, Mouse

关联疾病

疾病名称

别名

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Priapism

Mentulagra	Priapism, Familial Idiopathic
Familial Idiopathic Priapism	Pathologic Erection
Painful Erection

Familial Cerebral Saccular Aneurysm

Familial Berry Aneurysm

Familial Intracranial Saccular Aneurysm

Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E	Primary Open Angle Glaucoma
POAG	Adult-Onset Primary Open Angle Glaucoma
Chronic Simple Glaucoma	GLC1E
Primary Open Angle Glaucoma 1e	Glaucoma, Open Angle, Primary

Disseminated Chorioretinitis

Acquired Hyperkeratosis

Acquired Keratoderma	Keratoderma - Acquired
Keratoderma, Acquired	Keratosis Blennorrhagica

Lipodystrophy, Familial Partial, Type 6

FPLD6	Lipe-Related Familial Partial Lipodystrophy
Familial Partial Lipodystrophy Type 6	Lipe-Related Fpld
Lipodystrophy, Familial Partial, Associated With Lipe Mutations	Familial Partial Lipodystrophy Associated With Lipe Mutations
Lipodystrophy, Familial Partial, 6

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Congenital Aneurysm Of Ascending Aorta
Familial Aortic Aneurysm	Familial Thoracic Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Pancreatic Cancer

Pancreatic Carcinoma	Familial Pancreatic Carcinoma
Pancreatic Neoplasm	Carcinoma Of Pancreas
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Pancreatic Carcinoma, Somatic	Pancreatic Cancer, Somatic
Ca Body Of Pancreas	Ca Head Of Pancreas
Ca Tail Of Pancreas	Malignant Neoplasm Of Body Of Pancreas
Malignant Neoplasm Of Head Of Pancreas	Malignant Neoplasm Of Tail Of Pancreas
Pancreas Neoplasm	Exocrine Cancer
Exocrine Pancreas Carcinoma	Hereditary Pancreatic Cancer
Hereditary Pancreatic Carcinoma	PNCA
Cancer Of The Pancreas	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14450	TGFBR3 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS14451	Tgfbr3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS14452	Tgfbr3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS14453	TGFBR3L Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-174529	Human TGFBR3 mRNA		/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	TGFBR3	VGNC	VGNC:66137
Canis familiaris	TGFBR3	VGNC	VGNC:54077
Macaca mulatta	TGFBR3	VGNC	VGNC:78339
Rattus norvegicus	TGFBR3	RGD	RGD:61821
Mus musculus	TGFBR3	MGD	MGI:104637
Bos taurus	TGFBR3	VGNC	VGNC:49979
Others	TGFBR3	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TGFBR3 - transforming growth factor beta receptor 3 Gene

关于 TGFBR3

功能概要

TGFBR3 基因产物(12)

TGFBR3 蛋白结构

TGFBR3 蛋白互作信息

重组 TGFBR3 蛋白

TGFBR3 抗体

关联疾病

直系同源

热门区域

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TGFBR3 - transforming growth factor beta receptor 3 Gene

关于 TGFBR3

功能概要

TGFBR3 基因产物(12)

TGFBR3 蛋白结构

TGFBR3 蛋白互作信息

重组 TGFBR3 蛋白

TGFBR3 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z