1. Gene
  2. TPBG - trophoblast glycoprotein Gene

TPBG - trophoblast glycoprotein Gene

中文名称:滋养细胞糖蛋白

种属: Homo sapiens

同用名: 5T4; M6P1; 5T4AG; WAIF1

基因 ID: 7162 | 基因类型: protein coding

关于 TPBG

Cytogenetic location: 6q14.1 Genomic coordinates (GRCh38): 6:82,362,983-82,367,420 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele and 185 orthologues. Ubiquitous expression in esophagus (RPKM 8.0), endometrium (RPKM 5.0) and 22 other tissues.

功能概要

该基因编码可能参与细胞粘附的富含亮氨酸的跨膜糖蛋白。所编码的蛋白质是一种对滋养层细胞具有特异性的癌胚抗原。在成人中,这种蛋白质在许多肿瘤细胞中高度表达,并且与许多癌症的不良临床结果有关。 5' UTR 中的交替剪接导致编码相同蛋白质的多个转录变体。[RefSeq 提供,2009 年 10 月]

This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]

TPBG 基因产物(3)

mRNA Protein Name
NM_001166392.2 NP_001159864.1 trophoblast glycoprotein precursor
NM_001376922.1 NP_001363851.1 trophoblast glycoprotein precursor
NM_006670.5 NP_006661.1 trophoblast glycoprotein precursor

TPBG 蛋白结构

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (61 - 90)

LRR_8

LRR_8: Leucine rich repeat (93 - 154)

LRR_8

LRR_8: Leucine rich repeat (211 - 270)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (321 - 345)

  • 0
  • 100
  • 200
  • 300
  • 420 a.a.
蛋白主名 其他名称

trophoblast glycoprotein

5T4 oncofetal antigen

重组 TPBG 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70512 TPBG/5T4 Protein, Human (HEK293, His) Q13641 (S32-S355) ≥95%
HY-P71374 TPBG/5T4 Protein, Human (HEK293, mFc) Q13641 (S32-S355) ≥95%
HY-P72421 TPBG/5T4 Protein, Human (HEK293, Avi-His) Q13641 (S32-S355) ≥95%
HY-P78053 TPBG/5T4 Protein, Human (Biotinylated, HEK293, His-Avi) Q13641 (S32-S355) ≥95%
HY-P700840 TPBG/5T4 Protein, Human (FITC, HEK293, His-Avi) Q13641-1 (S32-S355) ≥95%
HY-P701049 TPBG/5T4 Protein, Human (HEK293, hFc) Q13641 (S32-S355) ≥95%

关联疾病

疾病名称 别名
Congenital Disorder Of Glycosylation, Type Il

Cdg Il

CDG1L

Cdgil

Congenital Disorder Of Glycosylation Il

Congenital Disorder Of Glycosylation 1l

Cdg-Il

Congenital Disorder Of Glycosylation Type Il

Glycosylation, Congenital Disorder Of, Type Il

Congenital Disorder Of Glycosylation Type 1l

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TPBG VGNC VGNC:47731
Felis catus TPBG VGNC VGNC:66469
Rattus norvegicus TPBG RGD RGD:621453
Bos taurus TPBG VGNC VGNC:36242
Mus musculus TPBG MGD MGI:1341264
Macaca mulatta TPBG VGNC VGNC:78631
Macaca fascicularis TPBG NCBI
Others TPBG NCBI