2. Gene
  3. Optn - optineurin Gene

Optn - optineurin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: NRP; FIP2; HYPL; 4930441O07Rik

基因 ID: 71648 | 基因类型: protein coding

关于 Optn

功能概要

Enables K63-linked polyubiquitin modification-dependent protein binding activity. Acts upstream of or within cellular protein localization and negative regulation of I-kappaB kinase/NF-kappaB signaling. Located in perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; eye; genitourinary system; musculoskeletal system; and nervous system. Human ortholog(s) of this gene implicated in Paget's disease of bone; amyotrophic lateral sclerosis (multiple); and glaucoma (multiple). Orthologous to human OPTN (optineurin). [provided by Alliance of Genome Resources, Apr 2022]

Optn 基因产物(2)

mRNA Protein Name
NM_001356487.1 NP_001343416.1 optineurin
NM_181848.5 NP_862896.1 optineurin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables K63-linked polyubiquitin modification-dependent protein binding IDA
IDA: 通过直接分析推断
17702576 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15607428 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within negative regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
17702576 MGI
acts upstream of or within protein localization IMP
IMP: 通过突变表型推断
15607428 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
15607428 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

optineurin

TFIIIA-INTP

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09809 OPTN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18146 Optn Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24621 Optn Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Optn NCBI NCBI:10133
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z