TTK - TTK protein kinase Gene

中文名称：TTK 蛋白激酶

种属: Homo sapiens

同用名: ESK; PYT; CT96; MPH1; MPS1; MPS1L1

基因 ID: 7272 | 基因类型: protein coding

关于 TTK

Cytogenetic location: 6q14.1 Genomic coordinates (GRCh38): 6:80,004,649-80,042,527 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues and 2 paralogues. Biased expression in testis (RPKM 13.6), bone marrow (RPKM 6.1) and 10 other tissues.

功能概要

该基因编码具有磷酸化酪氨酸、丝氨酸和苏氨酸能力的双重特异性蛋白激酶。与细胞增殖相关，这种蛋白质对于有丝分裂过程中着丝粒的染色体排列至关重要，并且是中心体复制所必需的。已发现它是一种关键的有丝分裂检查点蛋白，用于在有丝分裂期间准确分离染色体。当这种蛋白质不能降解并产生过多的中心体导致有丝分裂纺锤体异常时，可能会发生肿瘤发生。可变剪接导致多个转录本变体。[RefSeq 提供，2009 年 11 月]

This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during Mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during Mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

TTK 基因产物(2)

mRNA	Protein	Name
NM_001166691.2	NP_001160163.1	dual specificity protein kinase TTK isoform 2
NM_003318.5	NP_003309.2	dual specificity protein kinase TTK isoform 1

TTK 蛋白结构

Pkinase

0
200
400
600
800
857 a.a.

蛋白主名

其他名称

dual specificity protein kinase TTK

cancer/testis antigen 96

关联疾病

疾病名称

别名

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase

生物活性分子 (3)

目录号	产品名	作用方式	纯度	Phase
HY-101340A	Luvixasertib hydrochloride	Inhibitor	99.63%	Phase 2
HY-143904	PROTAC TTK degrader-1	Antagonist	98.01%	Phase 2
HY-101340	Luvixasertib	Inhibitor	99.77%	Phase 1

Pre-clinical Phase

生物活性分子 (22)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-116673	TTK21	Activator	99.39%	否
HY-14710	AZ3146	Inhibitor	99.42%	否
HY-108709	CC-671	Inhibitor	99.06%	否
HY-100024	NTRC 0066-0	Inhibitor	99.01%	否
HY-19544	JAK3-IN-1	Inhibitor	99.31%	否
HY-171770	dAurAB5		99.03%	否
HY-168543	PROTAC MPS1 degrader 2	Degrader	99.09%	否
HY-144308	RMS-07	Inhibitor	/	否
HY-132884	TTK inhibitor 3	Inhibitor	/	否
HY-110347	Mps1-IN-1 dihydrochloride	Inhibitor	/	否
HY-123675	CFI-400936	Inhibitor	/	否
HY-143905	PROTAC TTK degrader-2	Antagonist	/	否
HY-160419	Mps1-IN-8	Inhibitor	/	否
HY-162156	TTK inhibitor 4	Inhibitor	/	否
HY-164955	TTK/PLK1-IN-1	Inhibitor	/	否
HY-168540	PROTAC MPS1 degrader 1	Degrader	/	否
HY-168542	TTK ligand 2		/	否
HY-168545	TTK ligand 3		/	否
HY-RS15226	TTK Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS16792	Ttk Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS21071	Ttbk2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23232	Ttk Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	TTK	VGNC	VGNC:47971
Rattus norvegicus	TTK	RGD	RGD:1305558
Bos taurus	TTK	VGNC	VGNC:36487
Macaca mulatta	TTK	VGNC	VGNC:78670
Mus musculus	TTK	MGD	MGI:1194921
Felis catus	TTK	VGNC	VGNC:66683
Others	TTK	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4