2. Gene
  3. UBE2I - ubiquitin conjugating enzyme E2 I Gene

UBE2I - ubiquitin conjugating enzyme E2 I Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：泛素结合酶 E2 I

种属: Homo sapiens

同用名: P18; UBC9; C358B7.1

基因 ID: 7329 | 基因类型: protein coding

关于 UBE2I

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,309,152-1,327,017 (from NCBI)

This gene has 24 transcripts (splice variants), 243 orthologues and 24 paralogues. Ubiquitous expression in ovary (RPKM 23.2), endometrium (RPKM 17.8) and 25 other tissues.

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶：泛素激活酶或 E1、泛素结合酶或 E2，以及泛素-蛋白质连接酶或 E3。该基因编码 E2 泛素结合酶家族的成员。已发现该基因有四种编码相同蛋白质的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

UBE2I 基因产物(4)

mRNA Protein Name
NM_003345.5 NP_003336.1 SUMO-conjugating enzyme UBC9
NM_194259.3 NP_919235.1 SUMO-conjugating enzyme UBC9
NM_194260.3 NP_919236.1 SUMO-conjugating enzyme UBC9
NM_194261.3 NP_919237.1 SUMO-conjugating enzyme UBC9

UBE2I 蛋白结构

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (8 - 151)

  • 0
  • 100
  • 158 a.a.
蛋白主名 其他名称

SUMO-conjugating enzyme UBC9

RING-type E3 SUMO transferase UBC9

重组 UBE2I 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71403 UBE2I Protein, Human (GST) P63279 (M1-S158) ≥95%

关联疾病

疾病名称 别名
Microphthalmia

Microphthalmos

Isolated Anophthalmia-Microphthalmia Syndrome

Isolated Microphthalmia-Anophthalmia-Coloboma

Simple Microphthalmos

Clinical Anophthalmia

Isolated Anophthalmia - Microphthalmia

Isolated Pure Microphthalmia

Mac Spectrum

Microphthalmia-Anophthalmia-Coloboma Spectrum

Primitive Anophthalmia

Globe Of Eye Small

Small Eyeball

Hypoplasia Of Eye

Isolated Nanophthalmos

Rudimentary Eye

Dysplasia Of Eye
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15349 UBE2I Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta UBE2I VGNC VGNC:99624
Canis familiaris UBE2I VGNC VGNC:54084
Bos taurus UBE2I VGNC VGNC:36584
Mus musculus UBE2I MGD MGI:107365
Felis catus UBE2I VGNC VGNC:80700
Rattus norvegicus UBE2I RGD RGD:3926
Others UBE2I NCBI
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