2. Gene
  3. Als2 - alsin Rho guanine nucleotide exchange factor Gene

Als2 - alsin Rho guanine nucleotide exchange factor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Alsin; Als2cr6; mKIAA1563; 3222402C23Rik; 9430073A21Rik

基因 ID: 74018 | 基因类型: protein coding

关于 Als2

功能概要

Predicted to enable several functions, including GTPase regulator activity; protein homodimerization activity; and small GTPase binding activity. Acts upstream of or within several processes, including behavioral fear response; glutamatergic synaptic transmission; and receptor recycling. Located in several cellular components, including centrosome; lamellipodium; and ruffle. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; liver; and retina. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 2. Orthologous to human ALS2 (alsin Rho guanine nucleotide exchange factor ALS2). [provided by Alliance of Genome Resources, Apr 2022]

Als2 基因产物(3)

mRNA Protein Name
NM_001159948.2 NP_001153420.2 alsin isoform 1
NM_028717.6 NP_082993.4 alsin isoform 1
NM_146109.3 NP_666221.1 alsin isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17093100 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within behavioral fear response IMP
IMP: 通过突变表型推断
16107644 MGI
acts upstream of or within endosomal transport IMP
IMP: 通过突变表型推断
16321985 MGI
acts upstream of or within locomotory behavior IMP
IMP: 通过突变表型推断
16107644 MGI
acts upstream of or within neuromuscular junction development IMP
IMP: 通过突变表型推断
16321985 MGI
acts upstream of or within protein localization IMP
IMP: 通过突变表型推断
17093100 MGI
acts upstream of or within receptor recycling IMP
IMP: 通过突变表型推断
17093100 MGI
acts upstream of or within regulation of GTPase activity IDA
IDA: 通过直接分析推断
16085057 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
IDA: 通过直接分析推断
17093100 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IEP
IEP: 通过表达模式推断
17093100 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
IMP: 通过突变表型推断
17093100 MGI
acts upstream of or within response to oxidative stress IMP
IMP: 通过突变表型推断
16107644 MGI
acts upstream of or within synaptic transmission, glutamatergic IMP
IMP: 通过突变表型推断
17093100 MGI
acts upstream of or within vesicle organization IDA
IDA: 通过直接分析推断
16085057 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
16085057 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
16085057 MGI
located in dendritic spine IDA
IDA: 通过直接分析推断
17093100 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
17093100 MGI
is active in glutamatergic synapse IEP
IEP: 通过表达模式推断
17093100 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
17093100 MGI
located in lamellipodium IDA
IDA: 通过直接分析推断
15033976 MGI
is active in postsynaptic density IDA
IDA: 通过直接分析推断
17093100 MGI
located in postsynaptic density IDA
IDA: 通过直接分析推断
17093100 MGI
is active in postsynaptic density IMP
IMP: 通过突变表型推断
17093100 MGI
located in ruffle IDA
IDA: 通过直接分析推断
15033976 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

alsin

amyotrophic lateral sclerosis 2 (juvenile) homolog

amyotrophic lateral sclerosis 2 protein homolog

amyotrophic lateral sclerosis protein 2 homolog

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00634 ALS2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS00635 ALS2CL Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W611371 FP802 Inhibitor / 否
HY-RS17942 Als2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24413 Als2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Als2 NCBI NCBI:57679
Macaca fascicularis Als2 NCBI NCBI:101925534
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