2. Gene
  3. ZKSCAN1 - zinc finger with KRAB and SCAN domains 1 Gene

ZKSCAN1 - zinc finger with KRAB and SCAN domains 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：具有 KRAB 和 SCAN 结构域 1 的锌指

种属: Homo sapiens

同用名: KOX18; ZNF36; PHZ-37; ZNF139; ZSCAN33

基因 ID: 7586 | 基因类型: protein coding

关于 ZKSCAN1

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,015,596-100,045,374 (from NCBI)

This gene has 6 transcripts (splice variants), 94 orthologues and 31 paralogues. Ubiquitous expression in stomach (RPKM 13.7), skin (RPKM 12.9) and 25 other tissues.

功能概要

该基因编码 Kruppel C2H2 型锌指蛋白家族的一个成员。这种编码的蛋白质可能作为调节大脑中 GABA A 型受体表达的转录因子发挥作用。该基因的转录物已被证明可形成稳定且丰富的环状 RNA。已在胃癌中观察到该基因表达升高，编码的蛋白质可能刺激人胃癌细胞的迁移和侵袭。[RefSeq 提供，2016 年 10 月]

This gene encodes a member of the Kruppel C2H2-type zinc-finger family of proteins. This encoded protein may function as a transcription factor that regulates the expression of GABA type-A receptors in the brain. Transcripts from this gene have been shown to form stable and abundant circular RNAs. Elevated expression of this gene has been observed in gastric Cancer and the encoded protein may stimulate migration and invasion of human gastric Cancer cells. [provided by RefSeq, Oct 2016]

ZKSCAN1 基因产物(6)

mRNA Protein Name
NM_001287054.3 NP_001273983.1 zinc finger protein with KRAB and SCAN domains 1 isoform b
NM_001287055.3 NP_001273984.1 zinc finger protein with KRAB and SCAN domains 1 isoform c
NM_001346579.2 NP_001333508.1 zinc finger protein with KRAB and SCAN domains 1 isoform d
NM_001346580.2 NP_001333509.1 zinc finger protein with KRAB and SCAN domains 1 isoform b
NM_001346581.2 NP_001333510.1 zinc finger protein with KRAB and SCAN domains 1 isoform a
NM_003439.4 NP_003430.1 zinc finger protein with KRAB and SCAN domains 1 isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZKSCAN1 蛋白结构

SCAN

SCAN: SCAN domain (51 - 140)

KRAB

KRAB: KRAB box (227 - 262)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (392 - 415)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (419 - 444)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (448 - 471)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (475 - 499)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (507 - 528)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 563 a.a.
蛋白主名 其他名称

zinc finger protein with KRAB and SCAN domains 1

zinc finger protein 139

ZKSCAN1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZKSCAN1 P17029 MAPK7 Homo sapiens Q13164
Validated Y2H
32296183
种属内
ZKSCAN1 P17029 MAPK7 Homo sapiens Q13164
Y2H Array
32296183
种属内
ZKSCAN1 P17029 MAPK7 Homo sapiens Q13164
Y2H Prey Pooling
32296183
种属内
ZKSCAN1 P17029 ZSCAN32 Homo sapiens Q9NX65
Y2H Prey Pooling
25416956
种属内
ZKSCAN1 P17029 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
种属内
ZKSCAN1 P17029 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
种属内
ZKSCAN1 P17029 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16081 ZKSCAN1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ZKSCAN1 VGNC VGNC:78899
Canis familiaris ZKSCAN1 VGNC VGNC:54094
Rattus norvegicus ZKSCAN1 RGD RGD:1560616
Mus musculus ZKSCAN1 MGD MGI:1921820
Bos taurus ZKSCAN1 VGNC VGNC:37188
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