2. Gene
  3. DSCC1 - DNA replication and sister chromatid cohesion 1 Gene

DSCC1 - DNA replication and sister chromatid cohesion 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：DNA 复制和姐妹染色单体凝聚力 1

种属: Homo sapiens

同用名: DCC1

基因 ID: 79075 | 基因类型: protein coding

关于 DSCC1

Cytogenetic location: 8q24.12 Genomic coordinates (GRCh38): 8:119,833,976-119,855,894 (from NCBI)

This gene has 2 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in lymph node (RPKM 3.7), appendix (RPKM 2.3) and 24 other tissues.

功能概要

CHTF18 (MIM 613201) 、CHTF8 (MIM 613202) 和 DSCC1 是替代复制因子 C (RFC) (参见 MIM 600404) 复合物的组分，该复合物在细胞周期的 S 期将 PCNA (MIM 176740) 加载到 DNA 上 (Merkle 等人 al., 2003 [PubMed 12766176]；Bermudez 等人，2003 [PubMed 12930902]) .[OMIM 提供，2009 年 12 月]

CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009]

DSCC1 基因产物(1)

mRNA Protein Name
NM_024094.3 NP_076999.2 sister chromatid cohesion protein DCC1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to DNA clamp loader activity IDA
IDA: 通过直接分析推断
12930902 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16682347 GOA
contributes to single-stranded DNA helicase activity IDA
IDA: 通过直接分析推断
12930902 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in maintenance of mitotic sister chromatid cohesion IMP
IMP: 通过突变表型推断
16682347 GOA
involved in positive regulation of DNA-directed DNA polymerase activity IDA
IDA: 通过直接分析推断
12930902 GOA
involved in post-translational protein acetylation IMP
IMP: 通过突变表型推断
19907496 GOA
involved in regulation of DNA replication IMP
IMP: 通过突变表型推断
19907496 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Ctf18 RFC-like complex IDA
IDA: 通过直接分析推断
12930902 GOA
located in chromatin IDA
IDA: 通过直接分析推断
16682347 GOA
located in chromosome, centromeric region IDA
IDA: 通过直接分析推断
16682347 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
16682347 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DSCC1 蛋白结构

Dcc1

Dcc1: Sister chromatid cohesion protein Dcc1 (42 - 358)

  • 0
  • 100
  • 200
  • 300
  • 393 a.a.
蛋白主名 其他名称

sister chromatid cohesion protein DCC1

defective in sister chromatid cohesion 1 homolog

DSCC1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DSCC1 Q9BVC3 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
种属内
DSCC1 Q9BVC3 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
种属内
DSCC1 Q9BVC3 FGFR3 Homo sapiens P22607
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Amelogenesis Imperfecta, Hypomaturation Type, Iia3

Amelogenesis Imperfecta Hypomaturation Type 2a3

AI2A3

Amelogenesis Imperfecta Hypomaturation Type Iia3

Amelogenesis Imperfecta, Type Iia3

Amelogenesis Imperfecta Type Iia3

Amelogenesis Imperfecta, Hypomaturation Type, 2a3
Cornelia De Lange Syndrome

De Lange Syndrome

Brachmann De Lange Syndrome

Brachmann-De Lange Syndrome

Cdls

Bdls

Typus Degenerativus Amstelodamensis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04019 DSCC1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21561 Dscc1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28079 Dscc1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris DSCC1 VGNC VGNC:51769
Mus musculus DSCC1 MGD MGI:1919357
Bos taurus DSCC1 VGNC VGNC:28217
Felis catus DSCC1 VGNC VGNC:61636
Macaca mulatta DSCC1 VGNC VGNC:71894
Rattus norvegicus DSCC1 RGD RGD:1561749
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