CHAC1 - ChaC glutathione specific gamma-glutamylcyclotransferase 1 Gene

中文名称：ChaC 谷胱甘肽特异性γ-谷氨酰环转移酶 1

种属: Homo sapiens

关于 CHAC1

功能概要

该基因编码 γ-谷氨酰环转移酶蛋白质家族的成员。编码的蛋白质已被证明可通过 Notch 受体的去甘氨酸化促进神经元分化，从而阻止受体成熟并抑制 Notch 信号传导。这种蛋白质也可能在未折叠的蛋白质反应以及细胞内谷胱甘肽水平和氧化平衡的调节中发挥作用。该基因表达升高可能表明乳腺癌和卵巢癌患者癌症复发的风险增加。[RefSeq 提供，2016 年 9 月]

This gene encodes a member of the gamma-glutamylcyclotransferase family of proteins. The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signaling. This protein may also play a role in the unfolded protein response, and in regulation of glutathione levels and oxidative balance in the cell. Elevated expression of this gene may indicate increased risk of Cancer recurrence among breast and ovarian Cancer patients. [provided by RefSeq, Sep 2016]