2. Gene
  3. NAA60 - N-alpha-acetyltransferase 60, NatF catalytic subunit Gene

NAA60 - N-alpha-acetyltransferase 60, NatF catalytic subunit Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：N-α-乙酰转移酶 60，NatF 催化亚基

种属: Homo sapiens

同用名: HAT4; NatF; NAT15; hNaa60

基因 ID: 79903 | 基因类型: protein coding

关于 NAA60

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,443,611-3,486,963 (from NCBI)

This gene has 40 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in kidney (RPKM 15.2), duodenum (RPKM 14.4) and 25 other tissues.

功能概要

该基因编码一种定位于高尔基体的酶，在高尔基体中它将乙酰基转移到游离蛋白质的 N 末端。这种酶作用于组蛋白，其活性对染色质组装和染色体完整性很重要。可变剪接和替代启动子的使用会导致多种转录本变体。上游启动子位于差异甲基化区域 (DMR) 并进行印记；源自该位置的转录变体由母体等位基因表达。[RefSeq 提供，2015 年 11 月]

This gene encodes an enzyme that localizes to the Golgi apparatus, where it transfers an acetyl group to the N-terminus of free proteins. This enzyme acts on histones, and its activity is important for chromatin assembly and chromosome integrity. Alternative splicing and the use of alternative promoters results in multiple transcript variants. The upstream promoter is located in a differentially methylated region (DMR) and undergoes imprinting; transcript variants originating from this position are expressed from the maternal allele. [provided by RefSeq, Nov 2015]

NAA60 基因产物(9)

mRNA Protein Name
NM_001083600.3 NP_001077069.1 N-alpha-acetyltransferase 60 isoform a
NM_001083601.3 NP_001077070.1 N-alpha-acetyltransferase 60 isoform a
NM_001317093.1 NP_001304022.1 N-alpha-acetyltransferase 60 isoform b
NM_001317094.2 NP_001304023.1 N-alpha-acetyltransferase 60 isoform c
NM_001317095.2 NP_001304024.1 N-alpha-acetyltransferase 60 isoform d
NM_001317096.2 NP_001304025.1 N-alpha-acetyltransferase 60 isoform e
NM_001317097.2 NP_001304026.1 N-alpha-acetyltransferase 60 isoform f
NM_001317098.2 NP_001304027.1 N-alpha-acetyltransferase 60 isoform f
NM_024845.4 NP_079121.1 N-alpha-acetyltransferase 60 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone H4 acetyltransferase activity IDA
IDA: 通过直接分析推断
21981917 GOA
enables peptide alpha-N-acetyltransferase activity IDA
IDA: 通过直接分析推断
21750686 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
27320834 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in N-terminal peptidyl-methionine acetylation IDA
IDA: 通过直接分析推断
21750686 GOA
involved in N-terminal protein amino acid acetylation IDA
IDA: 通过直接分析推断
25732826 GOA
involved in cell population proliferation IMP
IMP: 通过突变表型推断
21981917 GOA
involved in nucleosome assembly IDA
IDA: 通过直接分析推断
21981917 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi membrane IDA
IDA: 通过直接分析推断
21981917 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NAA60 蛋白结构

Acetyltransf_1

Acetyltransf_1: Acetyltransferase (GNAT) family (60 - 156)

  • 0
  • 100
  • 200
  • 242 a.a.
蛋白主名 其他名称

N-alpha-acetyltransferase 60

N-acetyltransferase 15 (GCN5-related, putative)

NAA60 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NAA60 Q9H7X0 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
NAA60 Q9H7X0 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
NAA60 Q9H7X0 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
种属内
NAA60 Q9H7X0 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
种属内
NAA60 Q9H7X0 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
种属内
NAA60 Q9H7X0 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32814053
种属内
NAA60 Q9H7X0 SH3GLB1 Homo sapiens Q9Y371
Y2H Array
32814053
种属内
NAA60 Q9H7X0 SH3GLB1 Homo sapiens Q9Y371
Y2H Pooling
32814053
种属内
NAA60 Q9H7X0 CASP6 Homo sapiens P55212
Validated Y2H
32814053
种属内
NAA60 Q9H7X0 CASP6 Homo sapiens P55212
Y2H Array
32814053
种属内
NAA60 Q9H7X0 CASP6 Homo sapiens P55212
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Scheuermann Disease

Scheuermann'S Disease

Spinal Osteochondrosis

Juvenile Osteochondrosis Of Spine

Familial Scheuermann Disease

Familial Scheuermann Juvenile Kyphosis

Familial Spinal Osteochondrosis

Scheuermann Juvenile Kyphosis

Juvenile Osteochondritis Of The Spine

Juvenile Osteochondrosis Of Scheurermann

Scheuermann'S Kyphosis

Sherman'S Disease

Juvenile Kyphosis

Scheuermann Kyphosis

[X]Spinal Osteochondrosis, Unspecified
Microphthalmia, Syndromic 1

MCOPS1

Lenz Microphthalmia Syndrome

Lenz Dysplasia

Mcops4

Syndromic Microphthalmia 1

Lenz Microphthalmia

Maa

Microphthalmia Or Anophthalmos With Associated Anomalies

Syndromic Microphthalmia Type 4

Microphthalmia, Syndromic 4

Microphthalmia, Syndromic 4, Formerly

Mcops4, Formerly

Anop1, Formerly

Maa, Formerly

Lenz Type Microphthalmia

Syndromic Microphthalmia 4

Microphthalmia Lenz Type

Microphthalmia Syndromic 1

Syndromic Microphthalmia Type 1

Microphthalmia Syndromic 4

Microphthalmia With Ankyloblepharon And Intellectual Disability

Microphthalmia, Lenz Type

Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome

Microphthalmia, Syndromic, 1

Anop1

Microphthalmia, Syndromic, Type 1
Temple Syndrome

Uniparental Disomy, Maternal, Chromosome 14

Temple Syndrome Due To Paternal 14q32.2 Microdeletion

Paternal Del(14)(Q32.2)

Temple Syndrome Due To Paternal 14q32.2 Hypomethylation

Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14

Upd(14)Mat
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08992 NAA60 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus NAA60 VGNC VGNC:84247
Mus musculus NAA60 MGD MGI:1922013
Canis familiaris NAA60 VGNC VGNC:84246
Macaca mulatta NAA60 VGNC VGNC:96720
Rattus norvegicus NAA60 RGD RGD:1308915
Felis catus NAA60 VGNC VGNC:80603
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