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  2. GLRA3 - glycine receptor alpha 3 Gene

GLRA3 - glycine receptor alpha 3 Gene

中文名称:甘氨酸受体α3

种属: Homo sapiens

基因 ID: 8001 | 基因类型: protein coding

关于 GLRA3

Cytogenetic location: 4q34.1 Genomic coordinates (GRCh38): 4:174,636,920-174,829,247 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues and 45 paralogues. Biased expression in brain (RPKM 2.6), adrenal (RPKM 0.4) and 1 other tissue.

功能概要

该基因编码配体门控离子通道蛋白家族的一个成员。编码的蛋白质是甘氨酸受体亚家族的成员。可变剪接导致多个转录本变体。[RefSeq 提供,2013 年 11 月]

This gene encodes a member of the ligand-gated ion channel protein family. The encoded protein is a member of the glycine receptor subfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

GLRA3 基因产物(2)

mRNA Protein Name
NM_001042543.3 NP_001036008.1 glycine receptor subunit alpha-3 isoform b precursor
NM_006529.4 NP_006520.2 glycine receptor subunit alpha-3 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables extracellularly glycine-gated chloride channel activity IDA
IDA: 通过直接分析推断
26416729 GOA
enables glycine-gated chloride ion channel activity IDA
IDA: 通过直接分析推断
9677400 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chloride transmembrane transport IDA
IDA: 通过直接分析推断
9677400 GOA
involved in protein homooligomerization IDA
IDA: 通过直接分析推断
26416729 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of glycine-gated chloride channel complex IDA
IDA: 通过直接分析推断
9677400 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
26416729 GOA
located in plasma membrane IMP
IMP: 通过突变表型推断
9677400 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GLRA3 蛋白结构

Neur_chan_LBD

Neur_chan_LBD: Neurotransmitter-gated ion-channel ligand binding domain (47 - 253)

Neur_chan_memb

Neur_chan_memb: Neurotransmitter-gated ion-channel transmembrane region (260 - 370)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 464 a.a.
蛋白主名 其他名称

glycine receptor subunit alpha-3

glycine receptor, alpha-3 polypeptide

GLRA3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GLRA3 O75311 KCTD2 Homo sapiens Q14681 33961781
种属内
GLRA3 O75311 KCTD2 Homo sapiens Q14681 28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hyperekplexia

Hereditary Hyperekplexia

Kok Disease

Congenital Stiff Man Syndrome

Familial Startle Disease

Sthe

Stiff-Baby Syndrome

Hereditary Hyperexplexia

Startle Disease

Exaggerated Startle Reaction

Hyperexplexia Hereditary

Startle Disease, Familial

Startle Reaction, Exaggerated

Stiff-Man Syndrome, Congenital

Stiff-Person Syndrome, Congenital

Congenital Stiff-Man Syndrome

Congenital Stiff-Person Syndrome

Familial Hyperekplexia

Startle Syndrome

Stiff Baby Syndrome

Hyperekplexia, Hereditary

Stiff-Person Syndrome

Brain Stem Infarction

Brain Stem Infarctions

Brainstem Infarction

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive

Autosomal Recessive Mental Retardation

Autosomal Recessive Non-Syndromic Mental Retardation

Autosomal Recessive Non-Syndromic Intellectual Disability

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus GLRA3 RGD RGD:621229
Canis familiaris GLRA3 VGNC VGNC:41270
Mus musculus GLRA3 MGD MGI:95749
Felis catus GLRA3 VGNC VGNC:62590
Macaca mulatta GLRA3 VGNC VGNC:73076
Bos taurus GLRA3 VGNC VGNC:56969
Others GLRA3 NCBI