ZFP91 - ZFP91 zinc finger protein, atypical E3 ubiquitin ligase Gene

中文名称：ZFP91 锌指蛋白，非典型 E3 泛素连接酶

种属: Homo sapiens

同用名: PZF; DSM8; DMS-8; DSM-8; FKSG11; ZFP-91; ZNF757

关于 ZFP91

功能概要

该基因编码的蛋白质是锌指蛋白家族的一员。该基因产物包含 C2H2 型结构域，这是在许多核酸结合蛋白中发现的经典锌指结构域。这种蛋白质作为淋巴毒素-β 受体信号转导中非经典 NF-kappaB 通路的调节剂发挥作用。可变剪接导致多个转录本变体。已鉴定出由 ZFP91 和下游 CNTF 基因序列组成的通读转录本变体，但它被认为是非编码的。 ZFP91 和 CNTF 的通读转录也已在小鼠中观察到。还在 2 号染色体上鉴定出与 ZFP91 相关的假基因。[RefSeq 提供，2010 年 10 月]

The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]