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  2. ZFP91 - ZFP91 zinc finger protein, atypical E3 ubiquitin ligase Gene

ZFP91 - ZFP91 zinc finger protein, atypical E3 ubiquitin ligase Gene

中文名称:ZFP91 锌指蛋白,非典型 E3 泛素连接酶

种属: Homo sapiens

同用名: PZF; DSM8; DMS-8; DSM-8; FKSG11; ZFP-91; ZNF757

基因 ID: 80829 | 基因类型: protein coding

关于 ZFP91

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:58,579,063-58,621,550 (from NCBI)

This gene has 1 transcript (splice variant), 235 orthologues and 36 paralogues. Broad expression in testis (RPKM 63.1), bone marrow (RPKM 24.8) and 25 other tissues.

功能概要

该基因编码的蛋白质是锌指蛋白家族的一员。该基因产物包含 C2H2 型结构域,这是在许多核酸结合蛋白中发现的经典锌指结构域。这种蛋白质作为淋巴毒素-β 受体信号转导中非经典 NF-kappaB 通路的调节剂发挥作用。可变剪接导致多个转录本变体。已鉴定出由 ZFP91 和下游 CNTF 基因序列组成的通读转录本变体,但它被认为是非编码的。 ZFP91 和 CNTF 的通读转录也已在小鼠中观察到。还在 2 号染色体上鉴定出与 ZFP91 相关的假基因。[RefSeq 提供,2010 年 10 月]

The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]

ZFP91 基因产物(2)

mRNA Protein Name
NM_001197051.2 NP_001183980.1 E3 ubiquitin-protein ligase ZFP91 isoform 2
NM_053023.5 NP_444251.1 E3 ubiquitin-protein ligase ZFP91 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
20682767 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of NF-kappaB-inducing kinase activity IDA
IDA: 通过直接分析推断
20682767 GOA
involved in protein K63-linked ubiquitination IDA
IDA: 通过直接分析推断
20682767 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ZFP91 蛋白结构

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (386 - 409)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (430 - 453)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 570 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase ZFP91

RING-type E3 ubiquitin transferase ZFP91

ZFP91 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZFP91 Q96JP5 UBE2I Homo sapiens Q7KZS0 32296183
种属内
ZFP91 Q96JP5 UBE2I Homo sapiens Q7KZS0 32296183
种属内
ZFP91 Q96JP5 UBE2I Homo sapiens Q7KZS0 32296183
种属内
ZFP91 Q96JP5 ZNF526 Homo sapiens Q8TF50 32296183
种属内
ZFP91 Q96JP5 ZNF526 Homo sapiens Q8TF50 32296183
种属内
ZFP91 Q96JP5 ZNF526 Homo sapiens Q8TF50 32296183
种属内
ZFP91 Q96JP5 TP53BP2 Homo sapiens Q05BL1 32296183
种属内
ZFP91 Q96JP5 TP53BP2 Homo sapiens Q05BL1 32296183
种属内
ZFP91 Q96JP5 TP53BP2 Homo sapiens Q05BL1 32296183
种属内
ZFP91 Q96JP5 POU6F2 Homo sapiens P78424 32296183
种属内
ZFP91 Q96JP5 POU6F2 Homo sapiens P78424 32296183
种属内
ZFP91 Q96JP5 POU6F2 Homo sapiens P78424 32296183
种属内
ZFP91 Q96JP5 ZFP41 Homo sapiens Q8N8Y5 32296183
种属内
ZFP91 Q96JP5 ZFP41 Homo sapiens Q8N8Y5 32296183
种属内
ZFP91 Q96JP5 ZFP41 Homo sapiens Q8N8Y5 32296183
种属内
ZFP91 Q96JP5 AGR2 Homo sapiens O95994 32296183
种属内
ZFP91 Q96JP5 AGR2 Homo sapiens O95994 32296183
种属内
ZFP91 Q96JP5 AGR2 Homo sapiens O95994 32296183
种属内
ZFP91 Q96JP5 CEP70 Homo sapiens Q8NHQ1 32296183
种属内
ZFP91 Q96JP5 CEP70 Homo sapiens Q8NHQ1 32296183
种属内
ZFP91 Q96JP5 CEP70 Homo sapiens Q8NHQ1 32296183
种属内
ZFP91 Q96JP5 PICK1 Homo sapiens Q9NRD5 32296183
种属内
ZFP91 Q96JP5 PICK1 Homo sapiens Q9NRD5 32296183
种属内
ZFP91 Q96JP5 PICK1 Homo sapiens Q9NRD5 32296183
种属内
ZFP91 Q96JP5 FAM9A Homo sapiens Q8IZU1 32296183
种属内
ZFP91 Q96JP5 FAM9A Homo sapiens Q8IZU1 32296183
种属内
ZFP91 Q96JP5 FAM9A Homo sapiens Q8IZU1 32296183
种属内
ZFP91 Q96JP5 TSPYL2 Homo sapiens Q9H2G4 32296183
种属内
ZFP91 Q96JP5 TSPYL2 Homo sapiens Q9H2G4 32296183
种属内
ZFP91 Q96JP5 TSPYL2 Homo sapiens Q9H2G4 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

ZFP91 抗体

目录号 产品名 应用 反应物种
HY-P84732 ZFP91 Antibody (YA4429) WB, IHC-P, ICC/IF, FC, ELISA Human

关联疾病

疾病名称 别名
Duane-Radial Ray Syndrome

Okihiro Syndrome

DRRS

Dr Syndrome

Duane Anomaly With Radial Ray Abnormalities And Deafness

Acrorenoocular Syndrome

Acrorenocular Syndrome

Duane Anomaly With Radial Abnormalities And Deafness

Acro-Renal-Ocular Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus ZFP91 MGD MGI:104854
Rattus norvegicus ZFP91 RGD RGD:628736
Macaca mulatta ZFP91 VGNC VGNC:101428