CDK2AP1 - cyclin dependent kinase 2 associated protein 1 Gene

中文名称：细胞周期蛋白依赖性激酶 2 相关蛋白 1

种属: Homo sapiens

同用名: DOC1; ST19; DORC1; doc-1; p12DOC-1

关于 CDK2AP1

功能概要

由该基因编码的蛋白质是一种细胞周期蛋白依赖性激酶 2 (CDK2) 相关蛋白，它被认为通过隔离单体 CDK2 和靶向 CDK2 进行蛋白水解来负向调节 CDK2 活性。发现该蛋白质还与 DNA 聚合酶 α/引物酶相互作用并介导大 p180 亚基的磷酸化，这表明在细胞周期的 S 期 DNA 复制中具有调节作用。这种蛋白质还形成核小体重塑和组蛋白去乙酰化 (NURD) 复合物的核心亚基，该复合物在表观遗传学上调节胚胎干细胞分化。因此，该基因在细胞周期和表观遗传调控中发挥作用。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2012 年 7 月]

The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]