SLC7A5 - solute carrier family 7 member 5 Gene

中文名称：溶质载体家族 7 成员 5

种属: Homo sapiens

同用名: E16; CD98; LAT1; 4F2LC; MPE16; D16S469E

基因 ID: 8140 | 基因类型: protein coding

关于 SLC7A5

Cytogenetic location: 16q24.2 Genomic coordinates (GRCh38): 16:87,830,023-87,869,507 (from NCBI)

This gene has 3 transcripts (splice variants), 244 orthologues and 12 paralogues. Broad expression in testis (RPKM 35.6), bone marrow (RPKM 34.4) and 17 other tissues.

功能概要

启用 L-亮氨酸跨膜转运蛋白活性； L-色氨酸跨膜转运蛋白活性；和甲状腺激素跨膜转运体活性。参与羧酸转运；甲状腺激素转运；和外源运输。位于胞质溶胶中；细胞内膜结合细胞器；和质膜。是膜的组成部分。氨基酸转运复合体的一部分；顶端质膜；和微绒毛膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables L-leucine transmembrane transporter activity; L-tryptophan transmembrane transporter activity; and thyroid hormone transmembrane transporter activity. Involved in carboxylic acid transport; thyroid hormone transport; and xenobiotic transport. Located in cytosol; intracellular membrane-bounded organelle; and plasma membrane. Is integral component of membrane. Part of amino acid transport complex; apical plasma membrane; and microvillus membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC7A5 基因产物(1)

mRNA	Protein	Name
NM_003486.7	NP_003477.4	large neutral amino acids transporter small subunit 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables L-leucine transmembrane transporter activity	IDA IDA: 通过直接分析推断	19075510	GOA
enables L-leucine transmembrane transporter activity	IMP IMP: 通过突变表型推断	24038088	GOA
enables L-tryptophan transmembrane transporter activity	IDA IDA: 通过直接分析推断	30867591	GOA
enables amino acid transmembrane transporter activity	IDA IDA: 通过直接分析推断	26305885	GOA
enables amino acid transmembrane transporter activity	IMP IMP: 通过突变表型推断	23567998	GOA
enables antiporter activity	IDA IDA: 通过直接分析推断	11847106	GOA
enables aromatic amino acid transmembrane transporter activity	IGI IGI: 通过遗传相互作用推断	15589117	GOA
enables neutral L-amino acid transmembrane transporter activity	IDA IDA: 通过直接分析推断	26305885	GOA
enables neutral L-amino acid transmembrane transporter activity	IMP IMP: 通过突变表型推断	17197568	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25998567	GOA
enables thyroid hormone transmembrane transporter activity	IDA IDA: 通过直接分析推断	26305885	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in L-histidine transport	IDA IDA: 通过直接分析推断	9751058	GOA
involved in L-leucine import across plasma membrane	IDA IDA: 通过直接分析推断	19075510	GOA
involved in L-leucine import across plasma membrane	IMP IMP: 通过突变表型推断	17197568	GOA
involved in L-leucine transport	IDA IDA: 通过直接分析推断	9751058	GOA
involved in L-tryptophan transmembrane transport	IDA IDA: 通过直接分析推断	30867591	GOA
involved in alanine transport	IDA IDA: 通过直接分析推断	18262359	GOA
involved in amino acid import across plasma membrane	IDA IDA: 通过直接分析推断	26305885	GOA
involved in amino acid import across plasma membrane	IMP IMP: 通过突变表型推断	23567998	GOA
involved in isoleucine transport	IDA IDA: 通过直接分析推断	11557028	GOA
involved in methionine transport	IDA IDA: 通过直接分析推断	11557028	GOA
acts upstream of negative regulation of gene expression	IMP IMP: 通过突变表型推断	24038088	GOA
involved in neutral amino acid transport	IDA IDA: 通过直接分析推断	11847106	GOA
involved in phenylalanine transport	IDA IDA: 通过直接分析推断	9751058	GOA
involved in phenylalanine transport	IGI IGI: 通过遗传相互作用推断	15589117	GOA
acts upstream of positive regulation of interleukin-17 production	IMP IMP: 通过突变表型推断	24038088	GOA
acts upstream of positive regulation of interleukin-4 production	IMP IMP: 通过突变表型推断	24038088	GOA
acts upstream of positive regulation of type II interferon production	IMP IMP: 通过突变表型推断	24038088	GOA
involved in proline transport	IDA IDA: 通过直接分析推断	10574970	GOA
involved in thyroid hormone transport	IDA IDA: 通过直接分析推断	11564694	GOA
involved in tryptophan transport	IDA IDA: 通过直接分析推断	10049700	GOA
involved in tyrosine transport	IDA IDA: 通过直接分析推断	11557028	GOA
involved in valine transport	IDA IDA: 通过直接分析推断	11557028	GOA
involved in xenobiotic transport	IMP IMP: 通过突变表型推断	23567998	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of amino acid transport complex	IDA IDA: 通过直接分析推断	30867591	GOA
located in apical plasma membrane	IDA IDA: 通过直接分析推断	11742812	GOA
located in membrane	IDA IDA: 通过直接分析推断	30867591	GOA
located in microvillus membrane	IDA IDA: 通过直接分析推断	26050671	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	9751058	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC7A5 蛋白结构

AA_permease_2

0
100
200
300
400
507 a.a.

蛋白主名

其他名称

large neutral amino acids transporter small subunit 1

4F2 light chain

SLC7A5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SLC7A5	Q01650	SLC3A2	Homo sapiens	P08195-1	GMS	31160781
种属内	SLC7A5	Q01650	SLC3A2	Homo sapiens	P08195-1	3D-EM	31160781
种属内	SLC7A5	Q01650	SLC3A2	Homo sapiens	P08195-1	Comigration in SDS	31160781
种属内	SLC7A5	Q01650	SLC3A2	Homo sapiens	P08195	Anti Tag CoIP	35271311

种属间: 跨种属相互作用 种属内: 同种属相互作用

SLC7A5 抗体

目录号	产品名	应用	反应物种
HY-P81448	SLC7A5/LAT1 Antibody (YA1193)	IHC-P	Human

关联疾病

疾病名称

别名

Lysinuric Protein Intolerance

LPI	Dibasic Amino Aciduria Ii
Hyperdibasic Aminoaciduria	Dibasic Aminoaciduria 2
Dibasicamino Aciduria Ii	Congenital Lysinuria
Lpi - Lysinuric Protein Intolerance

Phenylketonuria

Phenylalanine Hydroxylase Deficiency	PKU
Pah Deficiency	Folling Disease
Maternal Phenylketonuria	Phenylketonurias
Oligophrenia Phenylpyruvica	Hyperphenylalaninemia, Non-Pku Mild
Folling'S Disease	Phenylalaninemia
Mild Phenylketonuria	Mild Pku
Variant Pku	Variant Phenylketonuria
Mpku	Deficiency Disease, Phenylalanine Hydroxylase
Phenylketonuria, Maternal	Phenylalanine Hydroxylase Deficiency Disease
Hyperphenylalaninemic Embryopathy	Maternal Pku
Maternal Hyperphenylalaninemia	Phenylketonuric Embryopathy
Hyperphenylalaninemia	HPA
Non-Phenylketonuria Hyperphenylalaninemia	NON-PKU HPA
Phenylketonuria Maternal	Classical Phenylketonuria
Hyperphenylalaninaemia	Pku - [Phenylketonuria]

Maple Syrup Urine Disease

MSUD	Bckd Deficiency
Branched-Chain Ketoaciduria	Branched-Chain Alpha-Keto Acid Dehydrogenase Deficiency
Keto Acid Decarboxylase Deficiency	Maple Syrup Urine Disease, Type Ii
Branched Chain Ketoaciduria	Classic Maple Syrup Urine Disease
Intermittent Maple Syrup Urine Disease	Maple Syrup Urine Disease, Type Ia
Ketoacidaemia	Bckdh Deficiency
Branched-Chain 2-Ketoacid Dehydrogenase Deficiency	Thiamine-Responsive Maple Syrup Urine Disease
Intermediate Maple Syrup Urine Disease	Maple Syrup Urine Disease Type 1a
Maple Syrup Urine Disease Type 1b	Maple Syrup Urine Disease Type 2
Maple Syrup Urine Disease, Type Ib	Dihydrolipoamide Dehydrogenase Deficiency
Branched-Chain Ketoacid Dehydrogenase Deficiency	Maple Syrup Disease
Ketoacidemia	Classic Bckd Deficiency
Classic Msud	Classic Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency
Classic Branched-Chain Ketoaciduria	Thiamine-Responsive Bckd Deficiency
Thiamine-Responsive Msud	Thiamine-Responsive Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency
Intermittent Bckd Deficiency	Intermittent Msud
Intermittent Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency	Maple Syrup Urine Disease 1a
MSUD1A	Maple Syrup Urine Disease Type Ia
Msud Type Ia	Maple Syrup Urine Disease 1b
MSUD1B	Maple Syrup Urine Disease Type Ib
Msud Type Ib	Maple Syrup Urine Disease 2
MSUD2	Maple Syrup Urine Disease Type Ii
Msud Type Ii	Nadh Cytochrome B5 Reductase Deficiency
Lactic Acidosis, Congenital Infantile, Due To Lad Deficiency	Ketonemia
Maple Syrup Urine Disease, Type 1b	Ketoacid Decarboxylase Deficiency
Oxoacid Decarboxylase Deficiency	Branched Chain Ketoacid Dehydrogenase Deficiency
Msud - [Maple-Syrup-Urine Disease]	Ketoaminoacidaemia
Bckd - [Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency]	Maple-Syrup-Urine Disorder
Maple-Syrup-Urine Syndrome

Extrahepatic Bile Duct Adenocarcinoma

Adenocarcinoma Of The Extrahepatic Bile Duct

Adenocarcinoma Of Extrahepatic Bile Duct

Central Serous Chorioretinopathy

Central Serous Chorioretinopathy After Bone Marrow Transplantation	Central Serous Choroidopathy
Cscr	Central Serous Retinopathy
Central Serous Choroidoretinopathy

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Lip And Oral Cavity Cancer

Oral Cancer	Lip And Oral Cavity Carcinoma
Malignant Neoplasm Of Mouth

Hartnup Disorder

Hartnup Disease	HND
Neutral 1 Amino Acid Transport Defect	Neutral Amino Acid Transport Defect
Deficiency Of Tryptophan Oxygenase	Hartnup'S Disease
Aminoaciduria, Hartnup Type	Disorder Of Neutral Amino Acid Transport

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Cystinuria

CSNU	Cystinuria Type B
Cystinuria Type A	Cystinuria, Type I, Formerly
Csnu1, Formerly	Cystinuria, Type Ii, Formerly
Cystinuria, Type Iii, Formerly	Csnu3, Formerly
Cystinuria, Type Non-I, Formerly	Cystinuria-Lysinuria
Cystinuria-Lysinuria Syndrome	Csnu1
Csnu3	Cystinuria 1
Cystinuria Type A/B	Cystinuria Type I
Cystinuria Type Ii	Cystinuria Type Iii
Cystinuria Type Non-I	Cystinuria, Type A/B
Cystinuria Type 1	Cystinuria - Lysinuria
Csnu - [Cystinuria]	Cystine Disease

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-120139	KMH-233	Inhibitor	99.75%	否
HY-RS13331	SLC7A5 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17279	Slc7a5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23734	Slc7a5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	SLC7A5	MGD	MGI:1298205
Rattus norvegicus	SLC7A5	RGD	RGD:620639
Felis catus	SLC7A5	VGNC	VGNC:97632
Bos taurus	SLC7A5	VGNC	VGNC:52250
Canis familiaris	SLC7A5	VGNC	VGNC:53447
Macaca mulatta	SLC7A5	VGNC	VGNC:104750

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLC7A5 - solute carrier family 7 member 5 Gene

关于 SLC7A5

功能概要

SLC7A5 基因产物(1)

SLC7A5 蛋白结构

SLC7A5 蛋白互作信息

SLC7A5 抗体

关联疾病

直系同源

热门区域

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SLC7A5 - solute carrier family 7 member 5 Gene

关于 SLC7A5

功能概要

SLC7A5 基因产物(1)

SLC7A5 蛋白结构

SLC7A5 蛋白互作信息

SLC7A5 抗体

关联疾病

相关产品

直系同源

热门区域

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C

F

G

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