MADCAM1 - mucosal vascular addressin cell adhesion molecule 1 Gene

中文名称：粘膜血管寻址素细胞粘附分子 1

种属: Homo sapiens

同用名: MACAM1

基因 ID: 8174 | 基因类型: protein coding

关于 MADCAM1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:496,486-505,343 (from NCBI)

This gene has 5 transcripts (splice variants) and 96 orthologues. Biased expression in appendix (RPKM 6.2), spleen (RPKM 4.9) and 6 other tissues.

功能概要

该基因编码的蛋白质是一种内皮细胞粘附分子，优先与骨髓细胞上的白细胞 beta7 整合素 LPAM-1 (alpha4beta7) 、L-选择素和 VLA-4 (alpha4beta1) 相互作用，以引导白细胞进入粘膜和发炎组织。它是免疫球蛋白家族的一员，类似于 ICAM1 和 VCAM1。已为该基因发现至少七个编码不同蛋白质亚型的可变剪接转录物，但尚未确定某些变体的全长性质。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 Integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

MADCAM1 基因产物(2)

mRNA	Protein	Name
NM_130760.3	NP_570116.2	mucosal addressin cell adhesion molecule 1 isoform a precursor
NM_130762.3	NP_570118.1	mucosal addressin cell adhesion molecule 1 isoform b precursor

MADCAM1 蛋白结构

Adhes-Ig_like

0
100
200
300
382 a.a.

蛋白主名

其他名称

mucosal addressin cell adhesion molecule 1

MAdCAM-1

重组 MADCAM1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71818	MAdCAM1 Protein, Human (P.pastoris, His-Myc)	Q13477 (19Q-317Q)	≥95%

关联疾病

疾病名称

别名

Colon Kaposi Sarcoma

Colonic Kaposi'S Sarcoma

Ileitis

Crohn'S Ileitis

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Colitis

Cholangitis

Acute Cholangiolitis	Ascending Cholangitis
Cholangiolitis	Cholangitis Nos
Chronic Cholangiolitis	Hepatic Duct Inflammation
Acute Cholangitis	Bile Duct Inflammation

Type 1 Diabetes Mellitus 21

Diabetes Mellitus, Insulin-Dependent, 21	Iddm21
T1D21	Insulin-Dependent Diabetes Mellitus 21

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma	Gastric Lymphoma, Primary
Lymphoma, Malt, Somatic	Mucosa-Associated Lymphoid Tissue Lymphoma
Extranodal Marginal Zone B-Cell Lymphoma	MALTOMA
Marginal Zone B-Cell Lymphoma	Mucosa-Associated Lymphatic Tissue Lymphoma
Primary Gastric Lymphoma	Gastric Lymphoma
Familial Primary Gastric Lymphoma

Progressive Multifocal Leukoencephalopathy

Pml	Leukoencephalopathy, Progressive Multifocal
Progressive Multifocal Leukoencephalitis	Leukoencephalopathy Progressive Multifocal
Pml - [Progressive Multifocal Leukoencephalopathy]

Listeria Meningitis

Meningitis, Listeria

Acquired Immunodeficiency Syndrome

Acquired Immune Deficiency Syndrome	AIDS
Acquired Immune Deficiency	Acquired Immunodeficiency
Acquired Immunodeficiency Due To Protein Loss

Ascending Cholangitis

Sclerosing Cholangitis

Fibrosing Cholangitis	Cholangitis, Sclerosing
Primary Sclerosing Cholangitis

Autoimmune Disease Of Gastrointestinal Tract

Gastroduodenal Crohn'S Disease

Upper Gi Crohn'S Disease

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07952	MADCAM1 Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	MADCAM1	RGD	RGD:3029
Canis familiaris	MADCAM1	VGNC	VGNC:42916
Felis catus	MADCAM1	VGNC	VGNC:68127
Mus musculus	MADCAM1	MGD	MGI:103579
Bos taurus	MADCAM1	VGNC	VGNC:31133
Others	MADCAM1	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)	站点地图隐私声明
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.	沪ICP备15051369号-4

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

站点地图隐私声明

MADCAM1 - mucosal vascular addressin cell adhesion molecule 1 Gene

关于 MADCAM1

功能概要

MADCAM1 基因产物(2)

MADCAM1 蛋白结构

重组 MADCAM1 蛋白

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

MADCAM1 - mucosal vascular addressin cell adhesion molecule 1 Gene

关于 MADCAM1

功能概要

MADCAM1 基因产物(2)

MADCAM1 蛋白结构

重组 MADCAM1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z