2. Immunology/Inflammation
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  4. Anti-Mouse MAdCAM-1 Antibody (MECA-367)

Anti-Mouse MAdCAM-1 Antibody (MECA-367) 

目录号: HY-P990197
技术支持

Anti-Mouse MAdCAM-1 Antibody (MECA-367) 是一种抗小鼠 MAdCAM-1 IgG2a 单克隆抗体。Anti-Mouse MAdCAM-1 Antibody (MECA-367) 通过阻断 MAdCAM-1 的功能显著抑制猪外周血淋巴细胞 (PBL) 的迁移。Anti-Mouse MAdCAM-1 Antibody (MECA-367) 选择性抑制 B 细胞迁移从而加剧炎症。抗小鼠Anti-Mouse MAdCAM-1 Antibody (MECA-367) 可用于研究炎症，代谢性疾病和异种移植，如结肠炎和糖尿病。

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Anti-Mouse MAdCAM-1 Antibody (MECA-367)

Anti-Mouse MAdCAM-1 Antibody (MECA-367) Chemical Structure

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Anti-Mouse MAdCAM-1 Antibody (MECA-367) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse MAdCAM-1 Antibody (MECA-367) is an anti-mouse MAdCAM-1 IgG2a monoclonal antibody. Anti-Mouse MAdCAM-1 Antibody (MECA-367) significantly inhibits the migration of pig peripheral blood lymphocytes (PBL) by blocking the function of MAdCAM-1. Anti-Mouse MAdCAM-1 Antibody (MECA-367) selectively inhibits B cell migration to exacerbate inflammation. Anti-Mouse MAdCAM-1 Antibody (MECA-367) can be used for researches on inflammation, metabolic conditions and xenotransplantation such as colitis and diabetes[1][2][3].

同型

Rat IgG2a kappa
推荐同型对照抗体
反应种属

Mouse
体内研究
(In Vivo)

Anti-Mouse MAdCAM-1 Antibody (MECA-367) (200 μg，静脉注射，单次剂量) 显著减少了 SCID 小鼠移植中猪外周血淋巴细胞 (PBL) 的迁移[1]。
Anti-Mouse MAdCAM-1 Antibody (MECA-367) (100 μg，腹腔注射，每周两次，持续 8 周) 可加重具有自发性慢性结肠炎 IL-10-/- 小鼠的结肠炎症状[2]。
Anti-Mouse MAdCAM-1 Antibody (MECA-367) (500 μg，腹腔注射，在第 0、2 和 4 天) 显著抑制 NOD-scid 小鼠的糖尿病[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1×108 PBL cells injected SCID mice[1]
Dosage: 200 μg
Administration: Intravenous injection (i.v.), single dose
Result: Significantly reduced the migration of porcine PBL in the graft and blocked its entry into the graft.
Animal Model: IL-10-/- mice with a spontaneous chronic colitis model[2]
Dosage: 100 μg
Administration: Intraperitoneal injection (i.p.), twice a week, for 8 weeks
Result: Led to a decrease in the number of B cells/antibody secreting cells (ASCs) in the colon.
Increased B cells in the spleen.
Significantly reduced fecal IgA/IgM and increased plasma IgA.
Reduced body weight and temperature, and increased colitis index.
Increased bacterial load, decreased alpha diversity, and altered beta diversity.
Animal Model: 1×107 BDC-2.5 T cells injected NOD scid mice (4-11 days)[3]
Dosage: 500 μg
Administration: Intraperitoneal injection (i.p.), on day 0, 2 and 4
Result: Significantly reduced the incidence rate of diabetes.
Accession

Q61826-1
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse MAdCAM-1 Antibody (MECA-367) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse MAdCAM-1 Antibody (MECA-367)L-SelectinCD62L| MAdCAM-1PBLB cellxenotransplantationcolitisdiabetesInhibitorinhibitorinhibit

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