1. Gene
  2. Pax8 - paired box 8 Gene

Pax8 - paired box 8 Gene

种属: Rattus norvegicus

基因 ID: 81819 | 基因类型: protein coding

关于 Pax8

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription, DNA-templated and sulfur compound metabolic process. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Human ortholog(s) of this gene implicated in congenital hypothyroidism and congenital nongoitrous hypothyroidism 2. Orthologous to human PAX8 (paired box 8). [provided by Alliance of Genome Resources, Apr 2022]

Pax8 基因产物(1)

mRNA Protein Name
NM_031141.2 NP_112403.2 paired box protein Pax-8
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
15888455 RGD
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
1508216 RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
1508216 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12441357 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
11145590 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9214635 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
1508216 RGD
involved in regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
11145590 RGD
involved in sulfur compound metabolic process IEP
IEP: 通过表达模式推断
12237116 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleoplasm IDA
IDA: 通过直接分析推断
12441357 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

paired box protein Pax-8

Pax-8 protein

paired box gene 8

Pax8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Pax8 P51974 Nkx2-1 Rattus norvegicus P23441 12441357
种属内
Pax8 P51974 Wbp2 Rattus norvegicus Q8R478 14531730
种属内
Pax8 P51974 Wbp2 Rattus norvegicus Q8R478 14531730
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pax8 NCBI NCBI:7849