2. Gene
  3. FZD8 - frizzled class receptor 8 Gene

FZD8 - frizzled class receptor 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：卷曲类受体 8

种属: Homo sapiens

同用名: FZ-8; hFZ8

基因 ID: 8325 | 基因类型: protein coding

关于 FZD8

Cytogenetic location: 10p11.21 Genomic coordinates (GRCh38): 10:35,638,247-35,642,296 (from NCBI)

This gene has 1 transcript (splice variant), 221 orthologues and 15 paralogues.

功能概要

这种无内含子的基因是卷曲基因家族的成员。该家族的成员编码七次跨膜结构域蛋白，这些蛋白是信号蛋白的 Wingless 型 MMTV 整合位点家族的受体。大多数 Frizzled 受体与 β-连环蛋白经典信号通路相耦合。该基因在两种人类癌细胞系中高度表达，表明它可能在多种类型的癌症中发挥作用。已经确定了类似小鼠蛋白质的胞外富含半胱氨酸结构域的晶体结构。[RefSeq 提供，2008 年 7 月]

This intronless gene is a member of the Frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most Frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human Cancer cell lines, indicating that it may play a role in several types of Cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]

FZD8 基因产物(1)

mRNA Protein Name
NM_031866.3 NP_114072.1 frizzled-8 precursor

FZD8 蛋白结构

Fz

Fz: Fz domain (35 - 149)

Frizzled

Frizzled: Frizzled/Smoothened family membrane region (267 - 622)

  • 0
  • 200
  • 400
  • 600
  • 694 a.a.
蛋白主名 其他名称

frizzled-8

frizzled 8, seven transmembrane spanning receptor

重组 FZD8 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70915 Frizzled-8 Protein, Human (HEK293, His) Q9H461 (A28-P172) ≥95%
HY-P72372 Frizzled-8 Protein, Human (Biotinylated, HEK293, His-Avi) Q9H461 (A28-P172) ≥95%

关联疾病

疾病名称 别名
Cystitis

Infective Cystitis

Urocystitis

Pyocystitis
Interstitial Cystitis

Bladder Pain Syndrome

Painful Bladder Syndrome

Ulcerative Cystitis

Ic/Bps

Ic/Pbs

Interstitial Cystitis/Bladder Pain Syndrome

Interstitial Cystitis/Painful Bladder Syndrome

Cystitis, Interstitial

Chronic Interstitial Cystitis

Pelvic Congestion Syndrome

Trigonitis
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Norrie Disease

Atrophia Bulborum Hereditaria

Episkopi Blindness

Pseudoglioma

ND

Norrie-Warburg Disease

Anderson-Warburg Syndrome

Fetal Iritis Syndrome

Norrie Syndrome

Norrie-Warburg Syndrome

Ndp

Congenital Progressive Oculo-Acoustico-Cerebral Degeneration

Norrie'S Disease

Oligophrenia Microphthalmus

Pseudoglioma Congenita

Whitnall-Norman Syndrome
Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy

Fevr

Criswick-Schepens Syndrome

Exudative Vitreoretinopathy, Familial

Vitreoretinopathy, Exudative )

Exudative Vitreoretinopathy 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99667 Ipafricept Inhibitor 99.80% Phase 1
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05184 FZD8 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus FZD8 RGD RGD:1560525
Bos taurus FZD8 VGNC VGNC:57008
Felis catus FZD8 VGNC VGNC:82431
Mus musculus FZD8 MGD MGI:108460
Macaca mulatta FZD8 VGNC VGNC:72838
Canis familiaris FZD8 VGNC VGNC:110465
Others FZD8 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z