DYNLRB1 - dynein light chain roadblock-type 1 Gene

中文名称：动力蛋白轻链路障 1 型

种属: Homo sapiens

同用名: BLP; BITH; DNCL2A; DNLC2A; ROBLD1

关于 DYNLRB1

功能概要

该基因是路障动力蛋白轻链家族的成员。编码的细胞质蛋白能够结合中间链蛋白，与转化生长因子-β 相互作用，并参与肌动蛋白调节蛋白的调节。该基因的上调与肝细胞癌有关，表明该基因可能参与肿瘤进展。可变剪接导致多个转录本变体。该基因的假基因已在 12 号和 18 号染色体上定义。[RefSeq 提供，2013 年 8 月]

This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013]