2. Gene
  3. PIP4K2B - phosphatidylinositol-5-phosphate 4-kinase type 2 beta Gene

PIP4K2B - phosphatidylinositol-5-phosphate 4-kinase type 2 beta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷脂酰肌醇 5-磷酸 4-激酶 2 型

种属: Homo sapiens

同用名: PI5P4KB; PIP5K2B; PIP5KIIB; PIP5P4KB; PIP5KIIbeta

基因 ID: 8396 | 基因类型: protein coding

关于 PIP4K2B

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,765,691-38,799,556 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 191 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 40.4), ovary (RPKM 23.8) and 24 other tissues.

功能概要

该基因编码的蛋白质催化肌醇环第四个羟基上的磷脂酰肌醇-5-磷酸磷酸化，形成磷脂酰肌醇-5,4-二磷酸。该基因是磷脂酰肌醇 5 磷酸 4 激酶家族的成员。编码的蛋白质序列与其他激酶没有相似性，但该蛋白质确实表现出激酶活性。此外，编码的蛋白质与 p55 TNF 受体相互作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to Other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF Receptor. [provided by RefSeq, Jul 2008]

PIP4K2B 基因产物(1)

mRNA Protein Name
NM_003559.5 NP_003550.1 phosphatidylinositol 5-phosphate 4-kinase type-2 beta
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
IDA: 通过直接分析推断
9038203 GOA
enables ATP binding IDA
IDA: 通过直接分析推断
26774281 GOA
enables GTP binding IDA
IDA: 通过直接分析推断
26774281 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
9753329 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process IDA
IDA: 通过直接分析推断
26774281 GOA
involved in negative regulation of insulin receptor signaling pathway IMP
IMP: 通过突变表型推断
31091439 GOA
involved in positive regulation of autophagosome assembly IMP
IMP: 通过突变表型推断
25578879 GOA
involved in regulation of autophagy IMP
IMP: 通过突变表型推断
25578879 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in autophagosome IMP
IMP: 通过突变表型推断
25578879 GOA
located in nucleus IDA
IDA: 通过直接分析推断
30718367 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
30718367 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PIP4K2B 蛋白结构

PIP5K

PIP5K: Phosphatidylinositol-4-phosphate 5-Kinase (129 - 414)

  • 0
  • 100
  • 200
  • 300
  • 416 a.a.
蛋白主名 其他名称

phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1-phosphatidylinositol 5-phosphate 4-kinase 2-beta

重组 PIP4K2B 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700597 PIP4K2B Protein, Human (His) P78356 (S2-T416) ≥95%

关联疾病

疾病名称 别名
Developmental And Epileptic Encephalopathy 33

DEE33

Epileptic Encephalopathy, Early Infantile, 33

Eiee33

Developmental And Epileptic Encephalopathy, 33

Early Infantile Epileptic Encephalopathy 33

Encephalopathy, Epileptic, Early Infantile, Type 33
Cone-Rod Dystrophy 5

CORD5

Dystrophy, Cone-Rod, Type 5
Lateral Meningocele Syndrome

Lehman Syndrome

Lms

LMNS

Meningocele, Lateral Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-177432 TMX-4140 Inhibitor / 否
HY-RS10563 PIP4K2B Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PIP4K2B VGNC VGNC:32907
Macaca mulatta PIP4K2B VGNC VGNC:76004
Rattus norvegicus PIP4K2B RGD RGD:621710
Felis catus PIP4K2B VGNC VGNC:68865
Mus musculus PIP4K2B MGD MGI:1934234
Canis familiaris PIP4K2B VGNC VGNC:44571
Others PIP4K2B NCBI
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