Gsk3b - glycogen synthase kinase 3 beta Gene

种属: Rattus norvegicus

基因 ID: 84027 | 基因类型: protein coding

关于 Gsk3b

功能概要

Enables several functions, including ATP binding activity; protein kinase activity; and signaling receptor binding activity. Involved in several processes, including regulation of neuron projection development; regulation of synapse organization; and response to peptide. Located in several cellular components, including dendritic spine; membrane raft; and microtubule. Part of beta-catenin destruction complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Used to study several diseases, including middle cerebral artery infarction; myocardial infarction; neurodegenerative disease (multiple); sciatic neuropathy; and vascular dementia. Biomarker of several diseases, including artery disease (multiple); diabetic encephalopathy; mental depression; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, Apr 2022]

Gsk3b 基因产物(1)

mRNA	Protein	Name
NM_032080.1	NP_114469.1	glycogen synthase kinase-3 beta

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP binding	IDA IDA: 通过直接分析推断	16879317	RGD
enables integrin binding	IPI IPI: 通过物理相互作用推断	18677563	RGD
enables ionotropic glutamate receptor binding	IPI IPI: 通过物理相互作用推断	17329210	RGD
enables kinase activity	IDA IDA: 通过直接分析推断	1346104	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	9482734	RGD
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	16478782	RGD
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	2164470	RGD
enables protein serine/threonine kinase binding	IPI IPI: 通过物理相互作用推断	8524413	RGD
enables tau protein binding	IDA IDA: 通过直接分析推断	16735023	RGD
enables tau-protein kinase activity	IDA IDA: 通过直接分析推断	16735023	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in bone remodeling	IDA IDA: 通过直接分析推断	29224185	RGD
involved in cell growth involved in cardiac muscle cell development	IDA IDA: 通过直接分析推断	27854077	RGD
involved in cellular response to amyloid-beta	IDA IDA: 通过直接分析推断	26224839	RGD
involved in cellular response to dopamine	IEP IEP: 通过表达模式推断	20007479	RGD
involved in cellular response to erythropoietin	IEP IEP: 通过表达模式推断	17952604	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: 通过表达模式推断	18005341	RGD
involved in cellular response to iron(II) ion	IEP IEP: 通过表达模式推断	19608791	RGD
involved in cellular response to lithium ion	IEP IEP: 通过表达模式推断	18932008	RGD
involved in cellular response to mechanical stimulus	IDA IDA: 通过直接分析推断	20042609	RGD
involved in establishment of cell polarity	IDA IDA: 通过直接分析推断	12610628	RGD
involved in establishment of cell polarity	IMP IMP: 通过突变表型推断	15652487	RGD
involved in establishment or maintenance of cell polarity	IDA IDA: 通过直接分析推断	12610628	RGD
involved in hepatic stellate cell activation	IMP IMP: 通过突变表型推断	28061416	RGD
involved in hepatocyte apoptotic process	IDA IDA: 通过直接分析推断	28638224	RGD
involved in maintenance of cell polarity	IMP IMP: 通过突变表型推断	15652487	RGD
involved in negative regulation of MAP kinase activity	IMP IMP: 通过突变表型推断	17182785	RGD
involved in negative regulation of dendrite development	IMP IMP: 通过突变表型推断	23470087	RGD
involved in negative regulation of dendrite morphogenesis	IMP IMP: 通过突变表型推断	17182785	RGD
involved in negative regulation of dopaminergic neuron differentiation	IMP IMP: 通过突变表型推断	15522889	RGD
involved in negative regulation of insulin receptor signaling pathway	IDA IDA: 通过直接分析推断	8524413	RGD
involved in negative regulation of neuron migration	IMP IMP: 通过突变表型推断	11403684	RGD
involved in negative regulation of nitric-oxide synthase activity	IMP IMP: 通过突变表型推断	18005341	RGD
involved in negative regulation of protein acetylation	IMP IMP: 通过突变表型推断	18268107	RGD
involved in negative regulation of protein localization to nucleus	IMP IMP: 通过突变表型推断	23624080	RGD
involved in negative regulation of smooth muscle cell apoptotic process	IMP IMP: 通过突变表型推断	21557011	RGD
involved in negative regulation of synaptic assembly at neuromuscular junction	IMP IMP: 通过突变表型推断	25764078	RGD
involved in neuron projection organization	IMP IMP: 通过突变表型推断	15652487	RGD
involved in positive regulation of DNA biosynthetic process	IMP IMP: 通过突变表型推断	12721208	RGD
involved in positive regulation of apoptotic process	IDA IDA: 通过直接分析推断	12393899	RGD
involved in positive regulation of apoptotic process	IMP IMP: 通过突变表型推断	12808104	RGD
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: 通过突变表型推断	20007479	RGD
involved in positive regulation of mitochondrial membrane potential	IMP IMP: 通过突变表型推断	19318234	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: 通过突变表型推断	16765055	RGD
involved in positive regulation of osteoblast proliferation	IMP IMP: 通过突变表型推断	26722385	RGD
involved in positive regulation of osteoclast differentiation	IMP IMP: 通过突变表型推断	28731198	RGD
involved in positive regulation of osteoclast proliferation	IMP IMP: 通过突变表型推断	26722385	RGD
involved in positive regulation of protein catabolic process	IMP IMP: 通过突变表型推断	17686886	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: 通过突变表型推断	21557011	RGD
involved in positive regulation of synaptic assembly at neuromuscular junction	IMP IMP: 通过突变表型推断	25764078	RGD
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	11035810	RGD
involved in regulation of axon extension	IMP IMP: 通过突变表型推断	15652487	RGD
involved in regulation of axonogenesis	IMP IMP: 通过突变表型推断	15652487	RGD
involved in regulation of dendrite morphogenesis	IMP IMP: 通过突变表型推断	15652487	RGD
involved in regulation of microtubule cytoskeleton organization	IMP IMP: 通过突变表型推断	18268107	RGD
involved in regulation of modification of postsynaptic structure	IDA IDA: 通过直接分析推断	23864697	RGD
involved in regulation of modification of postsynaptic structure	IMP IMP: 通过突变表型推断	23864697	RGD
involved in regulation of neuronal synaptic plasticity	IMP IMP: 通过突变表型推断	17329210	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: 通过直接分析推断	23864697	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: 通过突变表型推断	23864697	RGD
involved in regulation of osteoblast differentiation	IMP IMP: 通过突变表型推断	28731198	RGD
involved in response to L-glutamate	IEP IEP: 通过表达模式推断	18445133	RGD
involved in response to activity	IEP IEP: 通过表达模式推断	22252247	RGD
involved in response to angiotensin	IEP IEP: 通过表达模式推断	22982863	RGD
involved in response to epinephrine	IEP IEP: 通过表达模式推断	16934435	RGD
involved in response to estradiol	IEP IEP: 通过表达模式推断	22252247	RGD
involved in response to insulin	IEP IEP: 通过表达模式推断	16934435	RGD
involved in response to insulin-like growth factor stimulus	IEP IEP: 通过表达模式推断	17686886	RGD
involved in response to ultrasound	IEP IEP: 通过表达模式推断	20708505	RGD
involved in response to xenobiotic stimulus	IEP IEP: 通过表达模式推断	19359144	RGD
involved in response to zinc ion	IDA IDA: 通过直接分析推断	27295130	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in Schaffer collateral - CA1 synapse	IDA IDA: 通过直接分析推断	23864697	RGD
is active in Schaffer collateral - CA1 synapse	IMP IMP: 通过突变表型推断	23864697	RGD
located in axon	IDA IDA: 通过直接分析推断	15652487	RGD
part of beta-catenin destruction complex	IDA IDA: 通过直接分析推断	10228155	RGD
located in dendrite	IDA IDA: 通过直接分析推断	15652487	RGD
located in dendritic spine	IDA IDA: 通过直接分析推断	17329210	RGD
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	23864697	RGD
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	23864697	RGD
located in membrane	IDA IDA: 通过直接分析推断	16815997	RGD
located in microtubule	IDA IDA: 通过直接分析推断	8576078	RGD
part of protein-containing complex	IDA IDA: 通过直接分析推断	17329210	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

glycogen synthase kinase-3 beta

FA	GSK-3 beta
factor A	serine/threonine-protein kinase GSK3B

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-112388	GSK-3b Inhibitor XI	Inhibitor	99.10%	否
HY-RS05865	GSK3B Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17170	Gsk3b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23620	Gsk3b Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Gsk3b	NCBI	NCBI:2932
Mus musculus	Gsk3b	NCBI	NCBI:56637

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Gsk3b - glycogen synthase kinase 3 beta Gene

关于 Gsk3b

功能概要

Gsk3b 基因产物(1)

直系同源

热门区域

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Gsk3b - glycogen synthase kinase 3 beta Gene

关于 Gsk3b

功能概要

Gsk3b 基因产物(1)

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z