2. Gene
  3. MIEN1 - migration and invasion enhancer 1 Gene

MIEN1 - migration and invasion enhancer 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：迁移和入侵增强因子 1

种属: Homo sapiens

同用名: C35; ORB3; XTP4; RDX12; C17orf37

基因 ID: 84299 | 基因类型: protein coding

关于 MIEN1

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:39,728,510-39,730,532 (from NCBI)

This gene has 6 transcripts (splice variants), 196 orthologues and 2 paralogues. Ubiquitous expression in colon (RPKM 15.4), esophagus (RPKM 14.3) and 25 other tissues.

功能概要

参与细胞凋亡过程的负调控；细胞迁移的正调控；和 filopodium 组件的正向调节。位于多个蜂窝组件中，包括中心粒卫星；胞质溶胶；和核质。是质膜细胞质侧的固有成分。 [由基因组资源联盟提供，2022 年 4 月]

Involved in negative regulation of apoptotic process; positive regulation of cell migration; and positive regulation of filopodium assembly. Located in several cellular components, including centriolar satellite; cytosol; and nucleoplasm. Is intrinsic component of the cytoplasmic side of the plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

MIEN1 基因产物(2)

mRNA Protein Name
NM_001330206.2 NP_001317135.1 migration and invasion enhancer 1 isoform 2
NM_032339.5 NP_115715.3 migration and invasion enhancer 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
21068479 GOA
involved in positive regulation of cell migration IDA
IDA: 通过直接分析推断
21628459 GOA
involved in positive regulation of filopodium assembly IDA
IDA: 通过直接分析推断
21628459 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
21628459 GOA
located in cytosol IDA
IDA: 通过直接分析推断
21628459 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MIEN1 蛋白结构

Rdx

Rdx: Rdx family (24 - 95)

  • 0
  • 100
  • 115 a.a.
蛋白主名 其他名称

migration and invasion enhancer 1

HBV X-transactivated gene 4 protein

MIEN1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MIEN1 Q9BRT3 ZBTB32 Homo sapiens A0A0C4DGF1
Y2H Array
32296183
种属内
MIEN1 Q9BRT3 ZBTB32 Homo sapiens A0A0C4DGF1
Y2H Prey Pooling
32296183
种属内
MIEN1 Q9BRT3 VENTX Homo sapiens O95231
Y2H Array
32296183
种属内
MIEN1 Q9BRT3 VENTX Homo sapiens O95231
Y2H Prey Pooling
32296183
种属内
MIEN1 Q9BRT3 REL Homo sapiens Q04864-2
Y2H Array
32296183
种属内
MIEN1 Q9BRT3 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
种属内
MIEN1 Q9BRT3 POU6F2 Homo sapiens P78424
Y2H Array
32296183
种属内
MIEN1 Q9BRT3 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
种属内
MIEN1 Q9BRT3 HDAC7 Homo sapiens Q8WUI4-6
Y2H Array
32296183
种属内
MIEN1 Q9BRT3 HDAC7 Homo sapiens Q8WUI4-6
Y2H Prey Pooling
32296183
种属内
MIEN1 Q9BRT3 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
种属内
MIEN1 Q9BRT3 REL Homo sapiens Q04864
Validated Y2H
25416956
种属内
MIEN1 Q9BRT3 HLX Homo sapiens Q14774
Y2H Array
32296183
种属内
MIEN1 Q9BRT3 HLX Homo sapiens Q14774
Y2H Prey Pooling
32296183
种属内
MIEN1 Q9BRT3 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
种属内
MIEN1 Q9BRT3 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
种属内
MIEN1 Q9BRT3 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
种属内
MIEN1 Q9BRT3 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
种属内
MIEN1 Q9BRT3 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
种属内
MIEN1 Q9BRT3 TRIP6 Homo sapiens Q15654
Y2H Array
32296183
种属内
MIEN1 Q9BRT3 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
32296183
种属内
MIEN1 Q9BRT3 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
32296183
种属内
MIEN1 Q9BRT3 ARID5A Homo sapiens Q03989
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Breast Large Cell Neuroendocrine Carcinoma
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Brain Cancer

Adult Brain Tumor

Malignant Neoplasm Of Brain

Brain Neoplasms

Brain Neoplasm

Neoplasm Of Brain

Primary Malignant Neoplasm Of Brain

Brain Tumors

Adult Malignant Brain Neoplasm

Brain Neoplasm, Adult

Bt - Brain Tumour

Malignant Brain Tumour

Malignant Primary Brain Neoplasm

Malignant Primary Brain Tumor

Malignant Tumor Of Adult Brain

Malignant Tumor Of Brain

Primary Brain Neoplasm

Primary Brain Tumor

Tumor Of The Brain

Brain Tumor, Adult

Brain Tumor Primary

Malignant Primary Brain Tumors

Primary Brain Tumors

Cancer, Brain

Brain Tumor, Primary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08441 MIEN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19715 Mien1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26211 Mien1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus MIEN1 VGNC VGNC:63499
Mus musculus MIEN1 MGD MGI:1913678
Bos taurus MIEN1 VGNC VGNC:31468
Rattus norvegicus MIEN1 RGD RGD:1306682
Canis familiaris MIEN1 VGNC VGNC:43228
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