2. Gene
  3. CREB3L3 - cAMP responsive element binding protein 3 like 3 Gene

CREB3L3 - cAMP responsive element binding protein 3 like 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：cAMP 反应元件结合蛋白 3 like 3

种属: Homo sapiens

同用名: CREBH; HYTG2; CREB-H; HYST1481

基因 ID: 84699 | 基因类型: protein coding

关于 CREB3L3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,153,631-4,173,054 (from NCBI)

This gene has 5 transcripts (splice variants), 246 orthologues, 9 paralogues and is associated with 1 phenotype. Biased expression in small intestine (RPKM 71.0), duodenum (RPKM 67.5) and 1 other tissue.

功能概要

该基因编码碱性亮氨酸拉链家族和 AMP 依赖性转录因子家族的成员。编码的蛋白质定位于内质网，并充当由循环 AMP 刺激激活的转录因子。编码的蛋白质结合环 AMP 反应元件 (CRE) 和 box-B 元件，并与急性炎症反应、肝细胞癌、甘油三酯代谢和铁调素表达有关。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 12 月]

This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

CREB3L3 基因产物(4)

mRNA Protein Name
NM_001271995.2 NP_001258924.1 cyclic AMP-responsive element-binding protein 3-like protein 3 isoform b
NM_001271996.2 NP_001258925.1 cyclic AMP-responsive element-binding protein 3-like protein 3 isoform c
NM_001271997.2 NP_001258926.1 cyclic AMP-responsive element-binding protein 3-like protein 3 isoform d
NM_032607.3 NP_115996.1 cyclic AMP-responsive element-binding protein 3-like protein 3 isoform a

CREB3L3 蛋白结构

bZIP_1

bZIP_1: bZIP transcription factor (241 - 303)

  • 0
  • 100
  • 200
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  • 400
  • 461 a.a.
蛋白主名 其他名称

cyclic AMP-responsive element-binding protein 3-like protein 3

CREB/ATF family transcription factor

关联疾病

疾病名称 别名
Hypertriglyceridemia 2

HYTG2
Hypertriglyceridemia 1

Hypertriglyceridemia

Hypertriglyceridemia, Familial

Hypertriglyceridemia, Susceptibility To

HYTG1

FHTR

Hypertriglyceridemias Familial
Platyspondylic Lethal Skeletal Dysplasia, Torrance Type

PLSD-T

PLSDT

Platyspondylic Dysplasia, Torrance Type

Lethal Short-Limbed Platyspondylic Dwarfism, Torrance Type

Thanatophoric Dysplasia, Torrance Variant

Platyspondylic Skeletal Dysplasia, Torrance Type

Torrance Type Platyspondylic Dysplasia

Platyspondylic Dysplasia, Torrance-Luton Type

Platyspondylic Lethal Skeletal Dysplasia Torrance Type

Lethal Short-Limbed Platyspondylic Dwarfism Torrance Type

Thanatophoric Dysplasia Torrance Variant

Platyspondylic Chondrodysplasia, Torrance-Luton Type

Plsd-Tl

Dysplasia, Skeletal, Platyspondylic, Torrance Type
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Osteogenesis Imperfecta, Type Xix

OI19

Osteogenesis Imperfecta Type 19

Osteogenesis Imperfecta Type Xix

Osteogenesis Imperfecta, Type 19

Osteogenesis Imperfecta 19
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03152 CREB3L3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CREB3L3 RGD RGD:1308152
Macaca mulatta CREB3L3 VGNC VGNC:109609
Canis familiaris CREB3L3 VGNC VGNC:54593
Mus musculus CREB3L3 MGD MGI:2384786
Bos taurus CREB3L3 VGNC VGNC:27696
Felis catus CREB3L3 VGNC VGNC:61168
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