2. Gene
  3. KHSRP - KH-type splicing regulatory protein Gene

KHSRP - KH-type splicing regulatory protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：KH 型剪接调节蛋白

种属: Homo sapiens

同用名: p75; FBP2; KSRP; FUBP2

基因 ID: 8570 | 基因类型: protein coding

关于 KHSRP

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,413,102-6,424,811 (from NCBI)

This gene has 12 transcripts (splice variants), 244 orthologues and 12 paralogues. Ubiquitous expression in testis (RPKM 37.2), endometrium (RPKM 25.1) and 25 other tissues.

功能概要

KHSRP 基因编码一种多功能 RNA 结合蛋白，涉及多种细胞过程，包括转录、选择性前体 mRNA 剪接和 mRNA 定位 (Min 等人，1997 [PubMed 9136930]；Gherzi 等人，2004 [PubMed 15175153]) .[OMIM 提供，2010 年 4 月]

The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]

KHSRP 基因产物(3)

mRNA Protein Name
NM_001366299.1 NP_001353228.1 far upstream element-binding protein 2 isoform 2
NM_001366300.1 NP_001353229.1 far upstream element-binding protein 2 isoform 3
NM_003685.3 NP_003676.2 far upstream element-binding protein 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables mRNA 3'-UTR AU-rich region binding IDA
IDA: 通过直接分析推断
16126846 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16126846 GOA
enables protein folding chaperone EXP
EXP: 通过实验结果推断
19198587 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 3'-UTR-mediated mRNA destabilization IDA
IDA: 通过直接分析推断
16126846 GOA
involved in 3'-UTR-mediated mRNA destabilization IMP
IMP: 通过突变表型推断
28275056 GOA
involved in cellular response to cytokine stimulus IMP
IMP: 通过突变表型推断
16126846 GOA
involved in miRNA metabolic process IMP
IMP: 通过突变表型推断
27478153 GOA
involved in negative regulation of low-density lipoprotein particle clearance IGI
IGI: 通过遗传相互作用推断
26523989 GOA
involved in negative regulation of nitric oxide biosynthetic process IDA
IDA: 通过直接分析推断
16126846 GOA
involved in positive regulation of mRNA catabolic process IDA
IDA: 通过直接分析推断
16126846 GOA
involved in regulation of mRNA stability IDA
IDA: 通过直接分析推断
16126846 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KHSRP 蛋白结构

KH_1

KH_1: KH domain (146 - 208)

KH_1

KH_1: KH domain (236 - 299)

KH_1

KH_1: KH domain (327 - 386)

KH_1

KH_1: KH domain (427 - 491)

DUF1897

DUF1897: Domain of unknown function (DUF1897) (611 - 632)

DUF1897

DUF1897: Domain of unknown function (DUF1897) (666 - 692)

  • 0
  • 200
  • 400
  • 600
  • 711 a.a.
蛋白主名 其他名称

far upstream element-binding protein 2

FUSE-binding protein 2

KHSRP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
KHSRP Q92945 Ywhaz Mus musculus P63101
NMR
19198587
种属间
KHSRP Q92945 Ywhaz Mus musculus P63101
Y2H
17437629
种属间: 跨种属相互作用 种属内: 同种属相互作用

KHSRP 抗体

目录号 产品名 应用 反应物种
HY-P82398 KHSRP Antibody (YA2143) WB, IHC-P, ICC/IF, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Muscular Atrophy

Muscle Wasting

Amyotrophia

Wasting - Muscle

Skeletal Muscle Atrophy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-124648 SMN-C2 98.85% 否
HY-RS07242 KHSRP Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-106159 SB-T-101141 Inducer / 否
HY-RS18180 Khsrp Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24654 Khsrp Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris KHSRP VGNC VGNC:42340
Mus musculus KHSRP MGD MGI:1336214
Macaca mulatta KHSRP VGNC VGNC:74015
Bos taurus KHSRP VGNC VGNC:30545
Felis catus KHSRP VGNC VGNC:67938
Rattus norvegicus KHSRP RGD RGD:621828
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