DYNLL1 - dynein light chain LC8-type 1 Gene

中文名称：动力蛋白轻链 LC8-type 1

种属: Homo sapiens

同用名: LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1

关于 DYNLL1

功能概要

细胞质动力蛋白是分子量约为 1,200 kD 的大型酶复合物。它们包含两个主要由动力蛋白重链形成的力产生头，以及将头连接到基底域的茎，基底域包含数量不等的辅助中间链。该复合物参与细胞内运输和运动。该记录中描述的蛋白质是一条轻链，作为该复合物的一部分存在，但也与神经元一氧化氮合酶发生物理相互作用并抑制其活性。这种蛋白质的结合使神经元一氧化氮合酶二聚体不稳定，这是一种活动所必需的构象，并且它可以通过其对一氧化氮合酶活性的影响来调节许多生物过程。已经表征了替代转录剪接变体。[RefSeq 提供，2008 年 7 月]

Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]