GALR2 - galanin receptor 2 Gene

中文名称：甘丙肽受体 2

种属: Homo sapiens

同用名: GAL2-R; GALNR2; GALR-2

关于 GALR2

功能概要

甘丙肽是一种重要的神经调节剂，存在于大脑、胃肠系统和下丘脑垂体轴中。它是一种 30 氨基酸的非 C 末端酰胺化肽，可有效刺激生长激素分泌，抑制心脏迷走神经减慢心率，消除窦性心律失常，并抑制餐后胃肠蠕动。甘丙肽的作用是通过与属于 G 蛋白偶联受体 7 次跨膜家族成员的特定膜受体相互作用来介导的。 GALR2 与甘丙肽的 N 末端残基相互作用。 GALR2 的主要信号机制是通过磷脂酶 C/蛋白激酶 C 通路 (通过 Gq) ，与 GALR1 不同，GALR1 通过 Gi 抑制腺苷酸环化酶来传递其细胞内信号。然而，已经证明 GALR2 与 Gq 和 Gi 蛋白有效偶联以同时激活 2 个独立的信号转导通路。[RefSeq 提供，2008 年 7 月]

Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of Galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the Galanin peptide. The primary signaling mechanism for GALR2 is through the Phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]