AP1G2 - adaptor related protein complex 1 subunit gamma 2 Gene

中文名称：适配器相关蛋白复合物 1 亚基 γ 2

种属: Homo sapiens

同用名: G2AD

关于 AP1G2

功能概要

适应蛋白是网格蛋白包被的囊泡的重要组成部分，可将配体-受体复合物从质膜或跨高尔基体网络转运至溶酶体。适应蛋白家族由四类分子组成，分别称为α、β-、β-和γ-适应蛋白。适应蛋白与中、小亚基一起形成称为适配器的异四聚体复合物，其作用是促进网格蛋白包被的小坑和小泡的形成。该基因编码的蛋白质是一种γ-适应蛋白，属于衔接复合物大亚基家族。这种蛋白质连同复合物被认为在跨高尔基体网络和细胞表面之间的复杂通路中的某些运输步骤中发挥作用。[RefSeq 提供，2017 年 8 月]

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. [provided by RefSeq, Aug 2017]